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Neuropharmacology of emesis induced by anti-cancer therapy.
Abstract Cancer patients receiving certain cytotoxic therapies can experience severe nausea and vomiting, lasting for up to five days. Conventional antiemetic treatments may be poorly effective orExpand
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Treatment of nausea and vomiting: Gaps in our knowledge
The past 20 years have seen notable advances in our understanding of the physiology and pharmacology of the emetic reflex leading to the identification of the anti-emetic effects ofExpand
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Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury.
Neuropathic pain is associated with changes in the electrophysiological and neurochemical properties of injured primary afferent neurons. A mRNA differential display study in rat L(4/5) dorsal rootExpand
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Dorsal root ganglion neurons show increased expression of the calcium channel α2δ-1 subunit following partial sciatic nerve injury
Abstract Neuropathic pain is associated with changes in the electrophysiological and neurochemical properties of injured primary afferent neurons. A mRNA differential display study in rat L4/5 dorsalExpand
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Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.
5-HT4 receptors mediate several physiological effects of 5-HT, particularly in the central nervous system (CNS), heart and gut. Recently, several C-terminal splice variants of the human 5-HT4Expand
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Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders
The concept of the gut forming the centre of an integrated gut–brain–energy axis — modulating appetite, metabolism and digestion — opens up new paradigms for drugs that can tackle multiple symptomsExpand
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Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin
The peptide hormone ghrelin is known to be present within stomach and, to a lesser extent, elsewhere in gut. Although reports suggest that gastric function may be modulated by ghrelin acting via theExpand
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Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction.
Vagal afferents are extensively distributed in the digestive tract from the oesophagus to the colon. They are involved in the reflex control of normal gastrointestinal (GI) tract function (e.g.Expand
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A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research
The origins of the major classes of current anti-emetics are examined. Serendipity is a recurrent theme in discovery of their anti-emetic properties and repurposing from one indication to another isExpand
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The translational value of rodent gastrointestinal functions: a cautionary tale.
Understanding relationships between gene complements and physiology is important, especially where major species-dependent differences are apparent. Molecular and functional differences betweenExpand
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