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Prognostic Role of Myocardial Blood Flow Impairment in Idiopathic Left Ventricular Dysfunction
It is demonstrated that severely depressed MBF is a predictor of poor prognosis in patients with idiopathic LV dysfunction independently of the degree of LV functional impairment and of the presence of overt heart failure.
I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study
- D. Agostini, H. Verberne, A. Jacobson
- Medicine, BiologyEuropean Journal of Nuclear Medicine and…
- 1 March 2008
Application of a clinical trial methodology via the retrospective reanalysis of 123I-mIBG images confirms the previously reported prognostic value of this method in HF patients, including potential identification of a quantitative threshold for low risk for cardiac mortality and potentially fatal ventricular arrhythmias.
Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells
- S. Chiesa, S. Morbelli, A. Uccelli
- BiologyProceedings of the National Academy of Sciences
- 29 September 2011
It is shown that murine MSC impair Toll-like receptor-4 induced activation of DC resulting in the inhibition of cytokines secretion, down-regulation of molecules involved in the migration to the lymph nodes, antigen presentation to CD4+ T cells, and cross-presentation to CD8+ T Cells.
Metformin selectively affects human glioblastoma tumor-initiating cell viability
Data clearly suggest that metformin exerts antiproliferative activity on glioblastoma cells, showing a higher specificity toward tumor-initiating cells, and that the inhibition of Akt pathway may represent a possible intracellular target of this effect.
Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
- F. Nobili, G. Abbruzzese, G. Rodriguez
- Psychology, BiologyMovement disorders : official journal of the…
- 15 February 2009
Cortical dysfunction in Parkinson's disease patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD.
Homogeneously reduced versus regionally impaired myocardial blood flow in hypertensive patients: two different patterns of myocardial perfusion associated with degree of hypertrophy.
Evaluation of compartmental and spectral analysis models of [/sup 18/F]FDG kinetics for heart and brain studies with PET
- A. Bertoldo, P. Vicini, G. Sambuceti, A. Lammertsma, O. Parodi, C. Cobelli
- BiologyIEEE Transactions on Biomedical Engineering
- 1 December 1998
The authors propose here a new SA model which is more theoretically sound and indicates that heterogeneity in the brain is modest in the white matter and a higher than 60 min experimental time is preferable for brain studies.
Detection of Significant Coronary Artery Disease by Noninvasive Anatomical and Functional Imaging
In a multicenter European population of patients with stable chest pain and low prevalence of CAD, coronary computed tomographic angiography is more accurate than noninvasive functional testing for detecting significant CAD defined invasively.
Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder?
Unawareness of memory deficit in amnestic MCI: FDG-PET findings.
A significant correlation in all 42 aMCI patients points to posteromedial cortex as a key node of the network being involved in awareness of memory deficit, typical of Alzheimer's disease and therefore could be more at risk of developing dementia.