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The complexed structure and antimicrobial activity of a non‐β‐lactam inhibitor of AmpC β‐lactamase
β‐Lactamases are the major resistance mechanism to β‐lactam antibiotics and pose a growing threat to public health. Recently, bacteria have become resistant to β‐lactamase inhibitors, making thisExpand
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Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design.
The structures of AmpC beta-lactamase from Escherichia coli, alone and in complex with a transition-state analogue, have been determined by X-ray crystallography. The native enzyme was determined toExpand
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The p-C analyzing power between 100 and 750 MeV
Abstract The inclusive p-C analyzing power has been measured for laboratory scattering angles between 3° and 19° for energies between 80 and 584 MeV. The experiment was performed at LAMPF using aExpand
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Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.
The expression of beta-lactamases is the most common form of bacterial resistance to beta-lactam antibiotics. To combat these enzymes, agents that inhibit (e.g. clavulanic acid) or evade (e.g.Expand
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Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation
Molecular docking programs screen chemical databases for novel ligands that fit protein binding sites. When one compound fits the site well, close analogs typically do the same. Therefore, many ofExpand
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The use of computational methods in the discovery and design of kinase inhibitors.
The recent success of the first FDA-approved small-molecule tyrosine kinase inhibitor Gleevec (STI-571, imatinib mesylate) in the treatment of chronic myelogenous leukemia (CML) has focused attentionExpand
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Fast delta Hadamard transform.
We have developed both 1-D and 2-D methods (called fast delta Hadamard transforms, FDHT) which overcome both of the above limitations. Expand
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Granzymes as potential targets for rational drug design
A family of serine proteases, the granzymes, found in the dense cytoplasmic granules of lymphocytes/granulocytes have become targets of interest for rational drug design because of their role inExpand
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The experimental determination of the effective nucleon-nucleon interaction for p-nucleus reactions at intermediate energies
Abstract A complete measurement of the polarization transfer observables has been made for the first time in the (p, p') reaction at Intermediate energies. Measurements are reported for the 12 C(p,Expand
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