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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
It is shown that let-7 is a heterochronic switch gene that encodes a temporally regulated 21-nucleotide RNA that is complementary to elements in the 3′ untranslated regions of the heteroch chronic genes lin-14, lin-28, Lin-41, lin -42 and daf-12, indicating that expression of these genes may be directly controlled by let- 7. Expand
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
It is demonstrated that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3'UTR that are regulated by the heterochronic gene Lin-4. Expand
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity. Expand
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
It is shown that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 mutations. Expand
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Two small RNAs regulate the timing of Caenorhabditis elegans development and may control late temporal transitions during development across animal phylogeny. Expand
A uniform system for microRNA annotation.
Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that mi RNAs can be reliably distinguished from other RNAs such as small interfering RNAs. Expand
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
It is shown that null mutations in Daf-16 suppress the effects of mutations in daf-2 or age-1; lack of dAF-16 bypasses the need for this insulin receptor-like signalling pathway. Expand
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
- F. Slack, M. Basson, Z. Liu, V. Ambros, H. Horvitz, G. Ruvkun
- Biology, Medicine
- Molecular cell
- 1 April 2000
It is suggested that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29, and this work concludes that the C. elegans heterochronic gene lin-41 negatively regulates the timing of LIN-29 adult specification transcription factor expression. Expand
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Structural predictions and likely C-peptide cleavage sites typical of mammalian insulins suggest thatins-1 is most closely related to insulin, and overexpression of ins-1 causes partially penetrant arrest at the dauer stage and enhances dauer arrest in weak daf-2 mutants, suggesting that INS-1 and human insulin antagonize DAF-2 insulin-like signaling. Expand
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
It is shown that daf-28 encodes an insulin-like protein, which when mutated causes dauer arrest and down-regulation of DAF-2/IR signaling, and a dAF-28GFP fusion gene is expressed in ASI and ASJ, two sensory neurons that regulate dauer Arrest. Expand