• Publications
  • Influence
A 26-week inhalation toxicity study with formaldehyde in the monkey, rat, and hamster.
Nearly continuous exposure of monkeys and rats for six months at a level of 2.95 ppm of formaldehyde clearly elicited an effect while exposures below this level did not appear to demonstrate an effect, and it appeared that the monkey and rat were more sensitive to formaldehyde exposure than the hamster.
Environmental Risk Assessment of Trifluoroacetic Acid
The Montreal Protocol was developed in 1987 in response to concerns that the chlorofluorocarbons (CFCs) were releasing chlorine into the stratosphere and that this chlorine was causing a depletion of
Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats.
Inhalation exposure experiments with the direct-acting alkylating agent epichlorohydrin (ECH) were done on noninbred male Sprague-Dawley rats and a dose-rate effect was observed for ECH inasmuch as 30-day exposure to 100 ppm produced 15 cancers in comparison to the 1 cancer from the lifetime exposure to 30 ppm and no cancers from lifetime Exposure to 10 ppm.
Development of acute exposure guideline levels for airborne exposures to hazardous substances.
Acute exposure guideline levels (AEGLs) provide a viable approach for assisting in the prevention, planning, and response to acute airborne exposures to toxic agents.
Subchronic inhalation toxicity study of caprolactam (with a 4-week recovery) in the rat via whole-body exposures.
The whole-body exposure of Sprague-Dawley rats to caprolactam as a respirable aerosol for 13 weeks at gravimetrically determined levels of 24, 70, and 243 mg/m3 resulted in respiratory tract effects (laryngeal) at the highest exposure level with complete recovery within 4 weeks postexposure.
Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. I. Toxicity of 1,2,3-trichloropropane.
Repeated inhalation exposure and 1-generation reproduction studies have been conducted in the rat to address the adequacy of the 10 ppm occupational exposure limit established for
Acute inhalation study in the rat of comparative uptake, distribution and excretion for different cadmium containing materials.
It appeared that these cadmium compounds were not equivalent with respect to toxicity, absorption, distribution or excretion, and exposure to the two insoluble compounds did not produce mortality.
Two-Year Inhalation Toxicity Study in Rats with Hydrochlorofluorocarbon 123
Abstract Two-Year Inhalation Toxicity Study in Rats with Hydrochlorofluorocarbon 123. Malley, L. A., Carakostas, M., Hansen, J. F., Rusch, G. M., Kelly, D. P., and Trochimowicz, H. J. (1995). Fundam.
Acute, Subchronic, and Developmental Toxicity and Genotoxicity of 1,1,1-Trifluoroethane (HFC-143a)
The toxicity potential of 1,1,1-trifluoroethane (HFC-143a), a CFC alternative, was evaluated in several acute, subchronic, and developmental toxicity studies by the inhalation route and in
Subchronic inhalation toxicity studies with hydrochlorofluorocarbon 123 (HCFC 123).
Overall, HCFC 123 appears to have a low level of toxicity by the inhalation route, with no evidence for cumulative toxicity from multiple exposures in these studies.