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- Publications
- Influence
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration
- I. Tegeder, U. Muth-Selbach, +7 authors G. Geisslinger
- Medicine
- Clinical pharmacology and therapeutics
- 1 April 1999
The topical administration of non‐steroidal antiinflammatory drugs (NSAIDs) is widely used for the treatment of soft tissue pain. However, it is not known whether effective tissue concentrations are… Expand
Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2
- M. Kinzig-Schippers, U. Fuhr, +5 authors F. Soergel
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 March 1999
Pefloxacin is reported to cause clinically relevant inhibition of theophylline metabolism in vivo, but in vitro pefloxacin was only a weak inhibitor of the cytochrome P450 CYP1A2, mediating main… Expand
Lack of bioequivalence of a generic mefloquine tablet with the standard product
- E. Weidekamm, G. Ruesing, H. Caplain, F. Soergel, C. Crevoisier
- Medicine
- European Journal of Clinical Pharmacology
- 1 October 1998
AbstractObjective: To assess the bioequivalence between a generic tablet of mefloquine (Mephaquin® = M1) with the reference tablet (Lariam® = M2) in healthy volunteers.
Methods: This open label,… Expand
Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry
- M. Engler, G. Ruesing, F. Soergel, U. Holzgrabe
- Chemistry, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 May 1998
ABSTRACT Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass… Expand
Pancreatin micro pellets suitable for enteric coatings
- George Shlieout, Claus-Juergen Koelln, Frithjof Sczesny, J. F. Onken, Guido Ruesing
- Materials Science
- 15 August 2006
Bioäquivalenzuntersuchungen von Phytopharmaka — Grundlagen, Design, statistische Verfahren und moderne bioanalytische Nachweisverfahren
- F. Soergel, M. Kinzig-Schippers, G. Ruesing, M. Kellner
- Philosophy
- 1996
Fur die bezugnehmende Zulassung eines neuen Generikums genugt in der Regel die Bestimmung der Bioaquivalenz mit dem Referenzpraparat. Dazu ist der statistisch einwandfreie Beleg zu liefern, das die… Expand