• Publications
  • Influence
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration
The topical administration of non‐steroidal antiinflammatory drugs (NSAIDs) is widely used for the treatment of soft tissue pain. However, it is not known whether effective tissue concentrations areExpand
  • 92
  • 5
Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2
Pefloxacin is reported to cause clinically relevant inhibition of theophylline metabolism in vivo, but in vitro pefloxacin was only a weak inhibitor of the cytochrome P450 CYP1A2, mediating mainExpand
  • 35
  • 2
Lack of bioequivalence of a generic mefloquine tablet with the standard product
AbstractObjective: To assess the bioequivalence between a generic tablet of mefloquine (Mephaquin® = M1) with the reference tablet (Lariam® = M2) in healthy volunteers. Methods: This open label,Expand
  • 33
  • 1
Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry
ABSTRACT Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem massExpand
  • 30
Bioäquivalenzuntersuchungen von Phytopharmaka — Grundlagen, Design, statistische Verfahren und moderne bioanalytische Nachweisverfahren
Fur die bezugnehmende Zulassung eines neuen Generikums genugt in der Regel die Bestimmung der Bioaquivalenz mit dem Referenzpraparat. Dazu ist der statistisch einwandfreie Beleg zu liefern, das dieExpand