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Gene Ontology: tool for the unification of biology
The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
The genome sequence of Drosophila melanogaster.
The nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome is determined using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map.
Analysis of genetic mosaics in developing and adult Drosophila tissues.
This work has constructed a series of strains to facilitate the generation and analysis of clones of genetically distinct cells in developing and adult tissues of Drosophila, providing an unprecedented opportunity to perform systematic genetic screens for mutations affecting many biological processes.
Expression of baculovirus P35 prevents cell death in Drosophila.
This work expresses P35 in the developing embryo and eye of the fly Drosophila melanogaster and suggests that one mechanism by which viruses prevent the death of the host cell is to block a cell death pathway that mediates normally occurring cell death.
The neuronal architecture of the mushroom body provides a logic for associative learning
The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.
A GAL4-driver line resource for Drosophila neurobiology.
Genetic transformation of Drosophila with transposable element vectors.
A rosy transposon (ry1), constructed by inserting a chromosomal DNA fragment containing the wild-type rosy gene into a P transposable element, transformed germ line cells in 20 to 50 percent of the injected rosy mutant embryos indicating that the visible genetic defect in the host strain could be fully and permanently corrected by the transferred gene.
Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and Function
Gene Ontology Consortium: The Gene Ontology (GO) database and informatics resource
The Gene Ontology (GO) project provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences.
Tools for neuroanatomy and neurogenetics in Drosophila
- B. Pfeiffer, Arnim Jenett, G. Rubin
- BiologyProceedings of the National Academy of Sciences
- 15 July 2008
The results suggest that the D. melanogaster genome contains >50,000 enhancers and that multiple enhancers drive distinct subsets of expression of a gene in each tissue and developmental stage.