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The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
Nerve growth factor (NGF) promotes neuronal survival and differentiation and stimulates neurite outgrowth. NGF is synthesized as a precursor, proNGF, which undergoes post‐translational processing toExpand
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Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in rats.
The nucleus accumbens (NAc) plays a role in conditioned place preference (CPP). The authors tested the hypothesis that inhibition of mitogen-activated protein kinases (MAPKs) would inhibitExpand
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Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins
A role for Zn2+ in a variety of neurological conditions such as stroke, epilepsy and Alzheimer's disease has been postulated. In many instances, susceptible neurons are located in regions rich inExpand
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Management of oxidative stress by microalgae.
The aim of this review is to provide an overview of the current research on oxidative stress in eukaryotic microalgae and the antioxidant compounds microalgae utilize to control oxidative stress.Expand
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Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation.
Trypanosome trans-sialidase (TS) is a sialic acid-transferring enzyme that hydrolyzes alpha2,3-linked sialic acids and transfers them to acceptor molecules. Here we show that a highly purifiedExpand
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Optimization of staining conditions for microalgae with three lipophilic dyes to reduce precipitation and fluorescence variability
When the fluorescence signal of a dye is being quantified, the staining protocol is an important factor in ensuring accuracy and reproducibility. Increasingly, lipophilic dyes are being used toExpand
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Microalgae cultivation in a novel top-lit gas-lift open bioreactor.
This work investigated a top-lit open microalgae bioreactor that uses a gas-lift system to enable deeper production depths, thereby significantly reducing the footprint. Growth of Scenedesmus sp. inExpand
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Survival of Cholinergic Forebrain Neurons in Developing p75NGFR-Deficient Mice
The functions of the low-affinity p75 nerve growth factor receptor (p75NGFR) in the central nervous system were explored in vivo. In normal mice, approximately 25 percent of the cholinergic basalExpand
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Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat.
There is growing evidence that nerve growth factor (NGF) may function as a mediator of persistent pain states. We have identified a novel nonpeptidic molecule, ALE-0540, that inhibits the binding ofExpand
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