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Physiological and anatomical evidence for a magnocellular defect in developmental dyslexia.
Several behavioral studies have shown that developmental dyslexics do poorly in tests requiring rapid visual processing. In primates fast, low-contrast visual information is carried by theExpand
Developmental dyslexia: Four consecutive patients with cortical anomalies
We report the neuroanatomical findings in 4 consecutively studied brains of men with developmental dyslexia. The patients, who ranged in age between 14 and 32 years, were diagnosed as dyslexic duringExpand
Planum temporale asymmetry, reappraisal since Geschwind and Levitsky
Abstract This study utilizes the same brains reported by Geschwind and Levitsky [Science161, 186–187, 1968] and looks for indirect evidence for the Geschwind Hypothesis [Geschwind and Bahan, Proc.Expand
Evidence for aberrant auditory anatomy in developmental dyslexia.
Abnormal auditory processing in dyslexics suggests that accompanying anatomical abnormalities might be present in the auditory system. Therefore, we measured cross-sectional neuronal areas in theExpand
From genes to behavior in developmental dyslexia
All four genes thus far linked to developmental dyslexia participate in brain development, and abnormalities in brain development are increasingly reported in dyslexia. Comparable abnormalitiesExpand
The Collaborative Cross, a community resource for the genetic analysis of complex traits
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouseExpand
Common genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory andExpand
The effect of variation in expression of the candidate dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendritic morphology in the rat.
We investigated the postnatal effects of embryonic knockdown and overexpression of the candidate dyslexia gene homolog Kiaa0319. We used in utero electroporation to transfect cells in E15/16 ratExpand
The nature and identification of quantitative trait loci: a community's view
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci thatExpand
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
BackgroundSexual dimorphism in brain gene expression has been recognized in several animal species. However, the relevant regulatory mechanisms remain poorly understood. To investigate whetherExpand