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The prevalence of multiple sclerosis in the world: an update
- G. Rosati
- MedicineNeurological Sciences
- 1 April 2001
Prevalence data imply that racial and ethnic differences are important in influencing the worldwide distribution of MS and that its geography must be interpreted in terms of the probable discontinuous distribution of genetic susceptibility alleles, which can however be modified by environment.
The epidemiology of multiple sclerosis in Europe
Comparing epidemiological indices among European countries is a hard task and often leads only to approximate estimates, which represents a major methodological concern when evaluating the MS burden in Europe and when implementing specific cost‐of‐illness studies.
Vascular Factors and Risk of Dementia: Design of the Three-City Study and Baseline Characteristics of the Study Population
Objective: To describe the baseline characteristics of the participants in the Three-City (3C) Study, a study aiming to evaluate the risk of dementia and cognitive impairment attributable to vascular…
The worldwide prevalence of multiple sclerosis
A Descriptive Study of Epilepsy in the District of Copparo, Italy, 1964–1978
The view that the frequency of epilepsy in Italy as a whole is higher than that indicated by the Italian studies previously published is supported, and epilepsy is evenly distributed in Europe and the United States.
Overexpression of the Cytokine BAFF and Autoimmunity Risk
A TNFSF13B variant was associated with multiple sclerosis and SLE, and its effects were clarified at the population, cellular, and molecular levels.
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
A genome-wide association scan of ∼6.6 million genotyped or imputed variants in 882 Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of CBLB gene variants…
Inflammatory biomarkers in blood of patients with acute brain ischemia
In contrast to previous reports, interleukin‐6 (IL‐6) serum level showed a significant inverse correlation with both final neurological impairment and infarct size, suggesting that IL‐6, in the context of a complex pro‐inflammatory network occurring during stroke, is associated with neuroprotection rather than neurotoxicity in patients with ischemic brain injury.
The risk of Parkinson disease in Mediterranean people
The frequency of Parkinson disease on the island of Sardinia is studied to suggest racial differences in predisposition to Parkinson disease, and if Africans prove to be relatively unsusceptible to the disease, the risk for Sardinians and other Mediterranean ethnic groups might be intermediate between North Europeans and Africans.