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Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection
Findings contradict the dominant view that latent organisms exist in old classic tuberculous lesions, and have important implications for strategies aimed at the elimination of latent and persistent bacilli. Expand
Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes.
Findings help to explain claims for the efficacy of vitamin D in the treatment of some forms of tuberculosis, and also the occasional finding of raised serum calcium, and disturbed vitamin D metabolism in these patients. Expand
The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization.
- K. Dheda, J. Huggett, +5 authors Alimuddin Zumla
- Biology, Medicine
- Analytical biochemistry
- 1 September 2005
This report demonstrates that experimental results are highly dependent on the reference gene chosen, and normalized sets of data with convention-ally used reference genes, including conventionally chosen genes to address the impact of a validation exercise on intergroup comparisons. Expand
A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferon.
- G. Rook, J. Steele, S. Umar, H. Dockrell
- Chemistry, Medicine
- Journal of immunological methods
- 3 September 1985
A simple method by which the insoluble blue formazan dye produced by the reduction of nitro blue tetrazolium can be dissolved without heating using potassium hydroxide and dimethyl sulphoxide enhances the sensitivity and increases the applications of tests performed using the microELISA method. Expand
Microbes, immunoregulation, and the gut
Two distinct, but rapidly converging, areas of research have emphasised the need to understand, and ultimately to manipulate, the authors' physiological interactions with commensal flora, and with other transient but harmless organisms from the environment that affect immunoregulatory circuits. Expand
Smoking and tuberculosis: the epidemiological association and immunopathogenesis.
- P. Davies, W. Yew, +4 authors G. Rook
- Transactions of the Royal Society of Tropical…
- 1 April 2006
A likely possibility is that nicotine turns off the production of TNF-alpha by the macrophages in the lungs, rendering the patient more susceptible to the development of progressive disease from latent Mycobacterium tuberculosis infection. Expand
Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis.
The extent of type 2 cytokine gene expression in patients with pulmonary tuberculosis was studied by use of quantitative nested reverse-transcription polymerase chain reaction on freshly isolated peripheral blood mononuclear cells to support biologic significance of results. Expand
How environmental mycobacteria may predetermine the protective efficacy of BCG.
It is proposed that in those places where the environmental species prime for the Listeria-type of response subsequent BCG vaccination will afford good protection from both tuberculosis and leprosy, where the Koch- type of response frequently results from environmental contact BCG will be ineffective. Expand
Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance.
An important influence on this shift that has been largely ignored in in vitro work is the endocrine system. Expand
Progress in the immunology of the mycobacterioses.
- G. Rook
- Clinical and experimental immunology
- 1 July 1987
Sur les antigenes mycobacteriens protecteurs, les antigenes ou determinants antigeniques impliques dans les reponses des cellules T suppressives, les hypotheses pour expliquer la lepre lepromateuse,… Expand