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The Analysis of Cyanide and its Breakdown Products in Biological Samples
TLDR
Current bioanalytical techniques used for the verification of cyanide exposure are discussed, common problems associated with the analysis are identified, and the metabolism and toxicokinetics of cyanides and its breakdown products in biological systems are addressed.
Cyanide toxicokinetics: the behavior of cyanide, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid in multiple animal models.
TLDR
Concentrations of ATCA did not rise significantly above the baseline in the rat model, but rose quickly in rabbits and swine and then fell rapidly, generally following the relative behavior of cyanide, which reached a maximum in blood and declined rapidly in each animal model.
Simultaneous determination of cyanide and thiocyanate in plasma by chemical ionization gas chromatography mass-spectrometry (CI-GC-MS)
TLDR
An analytical method utilizing chemical ionization gas chromatography-mass spectrometry was developed and the toxicokinetic behavior of cyanide and thiocyanate in swine plasma was assessed following cyanide exposure.
Dimethyl trisulfide
TLDR
The fact that DMTS converts cyanide to thiocyanate more efficiently than does thiosulfate both with and without Rh makes it a promising sulfur donor-type cyanide antidote (scavenger) with reduced enzyme dependence in vitro.
Neurotoxicological and Behavioral Effects of Cyanide and Its Potential Therapies
The use of the blood agent cyanide (CN) as a military threat agent has been recognized not only historically (Nero and Napoleon III) but also more currently in World War I, World War II, in the
Optimization of Liposomal Lipid Composition for a New, Reactive Sulfur Donor, and In Vivo Efficacy Studies on Mice to Antagonize Cyanide Intoxication
TLDR
Data are indicating that the appropriately formulated DTO is a promising sulfur donor for cyanide antagonism, and prophylactic and therapeutic in vivo efficacy studies were carried out in a mice model.
Development of a Fluorescence-Based Sensor for Rapid Diagnosis of Cyanide Exposure
TLDR
A field sensor for the diagnosis of cyanide exposure was developed based on the reaction of naphthalene dialdehyde, taurine, and cyanide, yielding a fluorescent β-isoindole, which was 100% accurate in diagnosing cyanide poisoning for acutely exposed rabbits.
In vitro and in vivo comparison of sulfur donors as antidotes to acute cyanide intoxication
TLDR
These newly synthesized compounds provide a new rationale for anti‐CN drugs, with fewer side‐effects than the methemoglobin formers, and alter the chemical substituent of the longer chain sulfide modified the ability of the candidate SSD to protect against CN toxicity.
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