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The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency
Enterohaemorrhagic Escherichia coli attaches to the intestine through actin pedestals that are formed when the bacterium injects its protein EspFU (also known as TccP) into host cells. EspFU potentlyExpand
Stoichiometry of Nck-dependent actin polymerization in living cells
A combination of computational modeling and quantitative experimentation demonstrates that actin polymerization depends on Nck density as a result of a 4:2:1 Nck/N-WASp/Arp2/3 stoichiometry.
Inducible Clustering of Membrane-Targeted SH3 Domains of the Adaptor Protein Nck Triggers Localized Actin Polymerization
BACKGROUND SH2/SH3 adaptor proteins play a critical role in tyrosine kinase signaling pathways, regulating essential cell functions by increasing the local concentration or altering the subcellularExpand
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors
The dynamic reorganization of actin structures helps to mediate the interaction of cells with their environment. The Abl non-receptor tyrosine kinase can modulate actin rearrangement during cellExpand
Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.
The Nck family of Src homology (SH) 2/SH3 domain adaptors functions to link tyrosine phosphorylation induced by extracellular signals with downstream regulators of actin dynamics. We investigated theExpand
Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain
Angiogenesis in the developing central nervous system (CNS) is regulated by neuroepithelial cells, although the genes and pathways that couple these cells to blood vessels remain largelyExpand
A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.
Modulation of actin dynamics through the N-WASp/Arp2/3 pathway is important in cell locomotion, membrane trafficking, and pathogen infection. Here, we demonstrate that Nck is essential for actinExpand
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.
Cryptococcus neoformans (Cn) is a deadly fungal pathogen whose intracellular lifestyle is important for virulence. Host mechanisms controlling fungal phagocytosis and replication remain obscure.Expand
Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration
Planar and apical-basal cellular polarization of epithelia and endothelia are crucial during morphogenesis. The establishment of these distinct polarity states and their transitions are regulated byExpand
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics
Summary Directional migration requires the coordination of cytoskeletal changes essential for cell polarization and adhesion turnover. Extracellular signals that alter tyrosine phosphorylation driveExpand