• Publications
  • Influence
Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome.
BACKGROUND Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trendExpand
  • 355
  • 9
  • PDF
Emergence of New Delhi Metallo-Beta-Lactamase (NDM-1) and Klebsiella pneumoniae Carbapenemase (KPC-2) in South Africa
ABSTRACT This report documents emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in K. pneumoniae and Enterobacter cloacae in South Africa. NDM-1Expand
  • 105
  • 8
  • PDF
Emergence of OXA-48 and OXA-181 Carbapenemases among Enterobacteriaceae in South Africa and Evidence of In Vivo Selection of Colistin Resistance as a Consequence of Selective Decontamination of the
ABSTRACT This study reports on the emergence of OXA-48-like carbapenemases among isolates of Enterobacteriaceae in South Africa. In addition, the emergence during therapy of a colistin-resistantExpand
  • 89
  • 7
  • PDF
Unexpected Ebola virus in a tertiary setting: Clinical and epidemiologic aspects
Objectives: To describe the clinical manifestations of viral hemorrhagic fever, and to increase clinicians' awareness and knowledge of these illnesses. Design: Retrospective study of the clinical andExpand
  • 95
  • 6
The spread of carbapenem-resistant Enterobacteriaceae in South Africa: risk factors for acquisition and prevention.
New, effective antibiotics are only likely to become available in 15 - 20 years. To prevent deaths from untreatable Gram-negative infections in South Africa, the rights of any doctor, whether inExpand
  • 50
  • 6
  • PDF
The effect of penetrating trunk trauma and mechanical ventilation on the recovery of adult survivors after hospital discharge
Objectives. To establish whether survivors of penetrating trunk trauma recover adequately and spontaneously following critical illness. Material and methods. A prospective observational study wasExpand
  • 8
  • 5
  • PDF
Nosocomial Outbreak of Novel Arenavirus Infection, Southern Africa
This case reinforces the need for strict screening of internationally transferred patients.
  • 105
  • 4
  • PDF
Recommendations to achieve rapid therapeutic teicoplanin plasma concentrations in adult hospitalised patients treated for sepsis.
The optimum teicoplanin loading dose and duration of therapy required for rapid attainment of a therapeutic trough plasma concentration (C(min)) (> or = 10mg/L for serious Gram-positive infectionsExpand
  • 65
  • 3
Antimicrobial stewardship across 47 South African hospitals: an implementation study.
BACKGROUND The available data on antimicrobial stewardship programmes in Africa are scarce. The aims of this study were to assess the implementation of an antimicrobial stewardship programme in aExpand
  • 89
  • 3
  • PDF
Multicomponent antibiotic substances produced by fermentation: implications for regulatory authorities, critically ill patients and generics.
Teicoplanin and polymyxin E (colistin) are antibiotics consisting of multiple, closely related subcomponents, produced by fermentation. The principal components comprise a complex mixture ofExpand
  • 30
  • 3