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Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities.
- W. Lyons, L. Mamounas, L. Tessarollo
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 21 December 1999
The results indicate that endogenous BDNF is critical for the normal development and function of central 5-HT neurons and for the elaboration of behaviors that depend on these nerve cells, and BDNF(+/-) mice may provide a useful model to study human psychiatric disorders attributed to dysfunction of serotonergic neurons.
Amphetamine: effects on catecholamine systems and behavior.
The effects of AMPH in humans have close parallels in animals and at low doses, AMPH increases stereotypic locomotor activity and species-specific stereotypies at higher doses and interferes with intake.
Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine
Memory impairment in abstinent MDMA ("Ecstasy") users
The extent of memory impairment correlates with the degree of MDMA exposure and the reduction in brain 5-HT, as indexed by CSF 5-HIAA.
Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery
No loss of 5-HT nerve cell bodies in the rostral raphe nuclei was found, indicating that abnormal innervation patterns in MDMA-treated monkeys are not the result of loss of a particular 5- HT nerve cell group.
(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals
It is demonstrated, using principles of interspecies scaling, that dosages of MDMA known to be neurotoxic in animals fall squarely in the range of dosages used typically by recreational MDMA users.
Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study
Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.
- C. Scanzello, G. Hatzidimitriou, A. Martello, J. Katz, G. Ricaurte
- BiologyThe Journal of pharmacology and experimental…
- 1 March 1993
Examining the fate of 5-HT neurons in MDMA-treated rats revealed severe and enduring serotonergic deficits in multiple brain regions, and Morphologic immunocytochemical studies yielded results which corroborated the neurochemical findings.
Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428
- U. McCann, D. Wong, F. Yokoi, Victor Villemagne, R. Dannals, G. Ricaurte
- Biology, PsychologyThe Journal of Neuroscience
- 15 October 1998
Persistent reductions in DAT density in methamphetamine and methcathinone users are suggestive of loss of DAT or loss of DA terminals and raise the possibility that as these individuals age, they may be at increased risk for the development of parkinsonism or neuropsychiatric conditions in which brain DA neurons have been implicated.
Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans
- U. McCann, A. Ridenour, Y. Shaham, G. Ricaurte
- Biology, PsychologyNeuropsychopharmacology
- 1 April 1994
Differences in personality support the view that 5-HT systems are involved in modulating impulsive and aggressive personality traits and suggest that5-HT neurotoxicity may be a potential complication of MDMA use.