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Experimental NIDDM: Development of a New Model in Adult Rats Administered Streptozotocin and Nicotinamide
TLDR
This novel NID DM syndrome with reduced pancreatic insulin stores, which is similar to human NIDDM in that it has a significant response to glucose (although abnormal in kinetics) and preserved sensitivity to tolbutamide, may provide a particularly advantageous tool for pharmacological investigations of new insulinotropic agents. Expand
4-Hydroxyisoleucine: A Novel Amino Acid Potentiator of Insulin Secretion
TLDR
4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties and may be considered as a novel drug with potential interest for the treatment of NIDDM. Expand
A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion.
TLDR
Evidence is presented showing that a neuronal isoform of nitric oxide synthase (NOS) is expressed in rat pancreatic islets and INS-1 cells and suggests that an imbalance between these activities might be implicated in beta-cell dysregulation involved in certain pathological hyperinsulinic states. Expand
Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek
TLDR
It appears that saponins may be implicated, alone or together with diosgenin, in the observed hypocholesterolemic effect of fenugreek seeds in diabetic dogs. Expand
Steroid saponins from fenugreek seeds: Extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol
TLDR
It is shown that steroid saponins enhance food consumption and motivation to eat, and reduce plasma cholesterol levels in rats, which resulted in a progressive weight gain in these animals, in contrast to untreated diabetic controls. Expand
Effects of a fenugreek seed extract on feeding behaviour in the rat: Metabolic-endocrine correlates
TLDR
Investigation of the effects of a fenugreek seed extract on feeding behaviour in rats found it enhances food consumption and motivation to eat in rats and also induces hyperinsulinemia as well as hypocholesterolemia. Expand
Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.
TLDR
Findings clearly demonstrate that ID-1101 can reduce insulin resistance through activation of the early steps of insulin signaling in peripheral tissues and in liver, making it a potentially very valuable therapeutic agent for diabetes treatment. Expand
4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.
TLDR
In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of4-OH -Ile reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance. Expand
Antidiabetic Effects of Subtractions from Fenugreek Seeds in Diabetic Dogs
TLDR
The results show that the antidiabetic properties of fenugreek seeds are contained in the testa and endosperm, which is not possible to exclude the existence of one or more unknown active pharmacological compounds in this subfraction of the seed. Expand
4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion.
TLDR
The insulinotropic properties of 4-hydroxyisoleucine, in the micromolar range, are seen only in the presence of the linear major isoform; they also require carbon alpha in S-configuration, full methylation and carbon gamma-hydroxylation. Expand
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