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Mitochondrial Dysfunction and Psychiatric Disorders
TLDR
Energy impairment as a mechanism underlying the pathophysiology of some psychiatric disorders, like bipolar disorder, depression and schizophrenia, is discussed.
Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects.
TLDR
The results suggest that mitochondrial complex I dysfunction and oxidative stress play important roles in the pathophysiology of SZ and may be used in potential novel adjunctive therapy for SZ, focusing primarily on cognitive impairment and disorder progression.
In vitro effects of silver nanoparticles on the mitochondrial respiratory chain
TLDR
It is demonstrated that AgN (10, 25, and 50 mg l−1) decreases the activity of mitochondrial respiratory chain complexes I, II, III, and IV from all tissues.
Inhibition of Mitochondrial Respiratory Chain in the Brain of Adult Rats After Acute and Chronic Administration of Methylphenidate
TLDR
The results showed that complexes I, II, III and IV were inhibited after acute or chronic MPH administration in the hippocampus, prefrontal cortex, striatum and cerebral cortex, and cerebellum was not affected.
Mitochondrial dysfunction in obesity
TLDR
A general view about mitochondrial dysfunction in obesity is presented, including related alterations, such as inflammation, oxidative stress, and apoptosis, and focusing on the whole organism, covering alterations in peripheral tissues, BBB, and CNS.
The impact of obesity on neurodegenerative diseases
TLDR
This review aims to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations, and shows a strong correlation between obesity and the development of Alzheimer's disease and Parkinson's disease.
Oxidative Mechanisms of Brain Dysfunction During Sepsis
TLDR
The current knowledge on the role of free radicals in the development of brain dysfunction in sepsis focusing on oxidative damage and the redox control of brain inflammatory pathways is summarized.
Chronic administration of methylphenidate activates mitochondrial respiratory chain in brain of young rats
TLDR
It is suggested that chronic exposure to methylphenidate in young rats increases mitochondrial enzymes involved in brain metabolism, evaluated by glucose consumption.
Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain
TLDR
Evaluated the activities of succinate dehydrogenase (SDH) and cytochrome oxidase (COX) in rat brain after haloperidol, clozapine, olanzapine or aripiprazole chronic administration showed that antipsychotic drugs altered SDH activity but not COX.
Effect of Acute and Chronic Administration of Methylphenidate on Mitochondrial Respiratory Chain in the Brain of Young Rats
TLDR
The results showed that complexes I and III were not affected by chronic administration of methylphenidate and decreased complex I activity in cerebellum and prefrontal cortex, whereas complexes II, III and IV were not altered.
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