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Butyrylcholinesterase Is Associated With &bgr;-Amyloid Plaques in the Transgenic APPSWE/PSEN1dE9 Mouse Model of Alzheimer Disease
- S. Darvesh, M. Cash, G. Reid, E. Martin, A. Mitnitski, C. Geula
- Biology, Medicine
- Journal of neuropathology and experimental…
- 1 January 2012
Histochemical analysis of Alzheimer disease brain tissues indicates that butyrylcholinesterase (BuChE) is present in A&bgr;-amyloid plaques and may play a role in AD plaque maturation, and observations suggest that BuChE is associated with a subpopulation of A& bgr; plaques. Expand
Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model
The Knock-out of BChE in this model showed diminished fibrillar Aβ plaque deposition, more so in males than females, suggesting that lack of B ChE reduces deposition of fibrilar A β in AD and this effect may be influenced by sex. Expand
A significant reduction of the diaphragm in mdx:MyoD-/-(9th) embryos suggests a role for MyoD in the diaphragm development.
The data suggest that functions of MyoD and Myf5 (and the respective muscle precursor cell sub-populations) are not entirely redundant by term, as previously suggested, since My f5 is not capable of fully substituting for MyOD in the diaphragm development. Expand
Butyrylcholinesterase and the cholinergic system
Observations provide further neuroanatomical evidence of a role for BuChE in the regulation of acetylcholine levels in the CNS. Expand
Butyrylcholinesterase activity in multiple sclerosis neuropathology.
- S. Darvesh, A. Leblanc, +4 authors J. Fisk
- Chemistry, Medicine
- Chemico-biological interactions
- 6 September 2010
Altered alterations in BuChE activity in MS white matter lesions are demonstrated, including diminished enzyme activity associated with myelin and an increased activity in cells with microglial morphology, suggesting that BuE could be a potential target for novel disease-modifying strategies for MS. Expand
Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves 18FDG retention in 5XFAD mouse model of Alzheimer’s disease
In knocking out BChE and reducing fibrillar Aβ, a possible protective effect on brain function may be conferred in a number of structures in 5XFAD/BChE-KO mice. Expand
Synthesis and Preliminary Evaluation of Piperidinyl and Pyrrolidinyl Iodobenzoates as Imaging Agents for Butyrylcholinesterase
- Ian R Macdonald, G. Reid, +6 authors S. Darvesh
- Chemistry, Medicine
- Molecular Imaging and Biology
- 1 December 2011
BuChE-specific radiolabeled iodobenzoates enter the brain and, in general, label areas known to exhibit BuChE activity in histochemical studies may represent a new direction for the development of agents for the molecular imaging of butyrylcholinesterase in the living brain. Expand
Reduced fibrillar β-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model.
It is demonstrated that, as in the cerebral cortex, the absence of BChE leads to diminished fibrillar Aβ deposition in amygdala, hippocampal formation, thalamus and basal ganglia, with a trend towards such reduction in female mice. Expand
Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues.
Cholinesterase activity associated with neuritic plaques (NPs) and neurofibrillary tangles (NFTs) in Alzheimers disease (AD) brains exhibit altered histochemical properties, such as requiring lower… Expand
Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer’s Disease
- Ian R Macdonald, Selena P. Maxwell, G. Reid, M. Cash, D. Debay, S. Darvesh
- Journal of Alzheimer's disease : JAD
- 28 April 2017
The predictive value of BChE as a biomarker for AD that could facilitate timely disease diagnosis and management is highlighted and is compared to Aβ, thioflavin-S, and BE quantification of 26 postmortem brain tissues. Expand