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Interactions of 2,3‐benzodiazepines and cydothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices
1 The 2,3‐benzodiazepines GYKI 52466, GYKI 53405 and GYKI 53655 antagonized AMPA‐induced currents in cultured superior colliculus neurones in a non use‐dependent manner (steady state IC50S: GYKIExpand
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Interactions of GYKI 52466 and NBQX with cyclothiazide at AMPA receptors: experiments with outside-out patches and EPSCs in hippocampal neurones
In outside-out patches from cultured hippocampal neurones, glutamate (1 mM) applied for 1 ms evoked currents which rose rapidly (tau(on) 451 +/- 31 micros) to a peak and then deactivated with slowerExpand
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Effects of asiatic acid on passive and active avoidance task in male Spraque-Dawley rats.
AIM OF THE STUDY Centella asiatica has a reputation to restore declining cognitive function in traditional medicine. To date, only a few compounds that show enhancing learning and memory propertiesExpand
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α-Thujone reduces 5-HT3 receptor activity by an effect on the agonist-induced desensitization
Abstract The convulsant effects of α-thujone, the psychotropic component of absinthe, were attributed to inhibitory actions at the GABAA receptor. Here, we investigated for the first time the 5-HT3Expand
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Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide
Abstract We have analysed whether the expression of long-term potentiation (LTP) in rat hippocampal CA1 neurons involves a change in the kinetics ofExpand
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The Aβ aggregation modulator MRZ-99030 prevents and even reverses synaptotoxic effects of Aβ1-42 on LTP even following serial dilution to a 500:1 stoichiometric excess of Aβ1-42, suggesting a
MRZ-99030 (GAL-101) is a small molecule that promotes the formation of off-pathway, non-toxic amorphous clusters of Aβ thereby reducing the amount of toxic soluble oligomeric Aβ species. MRZ-99030Expand
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P1-016 A LATE EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR IS REQUIRED FOR THE SYNAPTIC REMODELING IN THE PERSISTENCE OF FEAR MEMORY
Background: Genetic analysis has been a potent tool in understanding processes involved in development and disease for more than a decade. However, differences in mRNA expression are not a reliableExpand
Anesthetic sPromotin gin vitro APP Metabolism and Amyloid- Toxicity
At present, more than 35 million people worldwide have Alzheimer's disease (AD). With increasing incidence and a growing number of aged patients undergoing surgery, the relevance of a possibleExpand
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