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The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain
ABSTRACT The protein kinase Bcr is a negative regulator of cell proliferation and oncogenic transformation. We identified Bcr as a ligand for the PDZ domain of the cell junction and Ras-interactingExpand
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c‐Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand‐of‐Numb protein X1
The very C‐terminus of c‐Src is a ligand for PDZ domains. In a screen for PDZ domains that interact with c‐Src, we identified one of the PDZ domains of the Ligand‐of‐Numb protein X1 (LNX1), aExpand
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Regulation of c‐Src by binding to the PDZ domain of AF‐6
c‐Src is a tightly regulated non‐receptor tyrosine kinase. We describe the C‐terminus of c‐Src as a ligand for a PDZ (postsynaptic density 95, PSD‐95; discs large, Dlg; zonula occludens‐1, ZO‐1)Expand
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RIP2 mediates LPS-induced p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte-derived dendritic cells.
IL-12, the critical factor for the generation of the Th1 type immune response, is produced by dendritic cells (DC) upon stimulation with LPS. Different signal pathways mediate LPS-induced expressionExpand
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Role of AF6 protein in cell‐to‐cell spread of Herpes simplex virus 1
AF6 and its rat homologue afadin are multidomain proteins localized at cell junctions and involved in intercellular adhesion. AF6 interacts via its PDZ domain with nectin‐1 at epithelial adherensExpand
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c-Src-Mediated Epithelial Cell Migration and Invasion Regulated by PDZ Binding Site
ABSTRACT c-Src tyrosine kinase controls proliferation, cell adhesion, and cell migration and is highly regulated. A novel regulatory mechanism to control c-Src function that has recently beenExpand
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Small‐Molecule Inhibitors of AF6 PDZ‐Mediated Protein–Protein Interactions
PDZ (PSD‐95, Dlg, ZO‐1) domains are ubiquitous interaction modules that are involved in many cellular signal transduction pathways. Interference with PDZ‐mediated protein–protein interactions hasExpand
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CNK1 controls invasiveness of breast cancer cells via transcriptional regulation of MT1-MMP through the PI3K-Akt-NF-κB signalling axis
The scaffold protein CNK1 was described to be involved in protooncogenic signalling pathways utilising protein kinases Raf-1 and Src and the small GTPase Rho. Deregulation of these molecules isExpand