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Effects of nine synthetic putative metabolites of primaquine on activity of the hexose monophosphate shunt in intact human red blood cells in vitro.
Suspensions of washed human red blood cells were treated with nine synthetic putative metabolic derivatives of primaquine (PQ'), and their individual effects on activity of the hexose monophosphateExpand
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Sustained release of an antimalarial drug using a copolymer of glycolic/lactic acid.
Abstract A copolymer of d1-lactic acid and glycolic acid (25% and 75% by weight, respectively) was evaluated as an implantable controlled release delivery system for the antimalarial drug 2,Expand
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Amino acid transport and incorporation in red blood cells of normal and Plasmodium knowlesi-infected rhesus monkeys.
Amino acid transport and incorporation in red blood cells of normal and Plasmodium knowlesi-infected rhesus monkeys. Experimental Parasitology 27, 143–149. Distribution ratios and incorporation intoExpand
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Sustained release of sulphadiazine
An implantable system was developed which released sulphadiazine in mice over an extended period of time efficacious against infective challenges by Plasmodium berghei. The most successfulExpand
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Plasmodium knowlesi: in vitro evaluation of antimalarial activity of folic acid inhibitors.
Abstract 14C-Orotic acid was incorporated into nucleic acids by Plasmodium knowlesi parasites during incubation in vitro. Incorporation into DNA was inhibited by antifolates. Inhibition by sulfaleneExpand
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In Vitro Antimalarial Activity of Nucleic Acid Precursor Analogues in the Simian Malaria Plasmodium knowlesi1
Analogues of nucleic acid precursors were screened for antimalarial activity in Plasmodium knowlesi by using an in vitro culture system. Activity was assessed by the degree of inhibition ofExpand
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Plasmodium knowlesi: in vitro biosynthesis of methionine.
Abstract Methionine biosynthesis was studied in rhesus monkey erythrocytes infected with Plasmodium knowlesi malaria which were cultured in vitro with l -[3-14C]serine, methyl-[14C]tetrahydrofolicExpand
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Sustained release of a dual antimalarial system
The sustained release of a dual drug system in a biodegradable carrier was evaluated in rhesus monkeys and mice. The two drugs were sulphadiazine (WR‐7557) (3H‐labelled) andExpand
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Plasmodium knowlesi: in vitro biosynthesis of methionine and thymidylic acid.
Abstract Methionine and thymidylic acid biosyntheses were studied to investigate methyl group sources in rhesus monkey erythrocytes infected with Plasmodium knowlesi malaria which were cultured inExpand
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Electrometric method for the determination of chloride in serum and other biologic fluids.
A direct titration procedure for chloride in serum, spinal fluid, urine, and other biologic materials has been described. It can be applied to tissues. It is recommended for its accuracy, precision,Expand
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