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Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
The α5 subunit of the GABAA receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of α5-containing GABAAExpand
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Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice
The α1β2γ2 is the most abundant subtype of the GABAA receptor and is localized in many regions of the brain. To gain more insight into the role of this receptor subtype in the modulation ofExpand
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The Role of the Instrumental Contingency in the Motivational Control of Performance
In four experiments we investigated an irrelevant incentive effect based upon a transition from hunger to thirst. Hungry rats were trained to lever press either for sucrose solution or for foodExpand
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Pavlovian Processes in the Motivational Control of Instrumental Performance
Hungry rats were rewarded for pressing a lever on a multiple schedule. During one component the reward was a sucrose solution, whereas food pellets acted as the reward during another component. LeverExpand
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Vortioxetine reduces BOLD signal during performance of the N-back working memory task: a randomised neuroimaging trial in remitted depressed patients and healthy controls
Cognitive dysfunction is common in depression during both acute episodes and remission. Vortioxetine is a novel multimodal antidepressant that has improved cognitive function including executiveExpand
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The effects of sibutramine on the microstructure of eating behaviour and energy expenditure in obese women
Given the suggestion that many potential anti-obesity drugs may enhance within-meal satiation, few studies have directly measured the effects of any drug on the microstructure of human eatingExpand
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Combined NK1 antagonism and serotonin reuptake inhibition: effects on emotional processing in humans
Background: Synergistic effects of NK1 receptor antagonism combined with serotonin reuptake inhibition have been reported in preclinical models. GSK424887 is a selective competitive antagonist of theExpand
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Assaying Aspects of Attention and Impulse Control in Mice Using the 5‐Choice Serial Reaction Time Task
First developed in the 1980s by Trevor Robbins in Cambridge to investigate attentional function in rats, the 5‐choice serial reaction time task involves continuous scanning by the subject across aExpand
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Motivational Control of Instrumental Performance: The Role of Prior Experience of The Reinforcer
In four experiments we investigated the conditions that are necessary for instrumental performance to adjust appropriately to a change in drive state. Rats were trained to press a lever and pull aExpand
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The effect of a clinically effective and non‐effective dose of lorazepam on 7.5% CO2‐induced anxiety
Symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by acute administration of GABAA receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effectsExpand
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