G. Quash

Publications86
h-index16
Citations879
Highly Influential Citations13
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α,β-Acetylenic amino thiolester inhibitors of aldehyde dehydrogenases 1&3: suppressors of apoptogenic aldehyde oxidation and activators of apoptosis.
The aim of this minireview is to recapitulate the evidence in the literature supporting a role for the aldehyde dehydrogenases (ALDH1, ALDH2 and ALDH3) in controlling the levels of 3 endogenous… Expand
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Red blood cell polyamines in mice bearing the lewis lung carcinoma (3ll) and in patients with bronchopulmonary cancers
(I) Experimentally, during Lewis lung carcinoma (3LL) growth, the red blood cell (RBC) polyamine levels increase with tumor volume and are inversely correlated to tumoral concentrations of spermidine… Expand
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Cell cycle kinetics, tissue transglutaminase and programmed cell death (apoptosis)
Studies were undertaken on a highly metastatic hamster fibrosarcoma cell line with a view to assessing whether cells entering into apoptosis, measured by counting the number of transglutaminase… Expand
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Transglutaminase activity and Nϵ(γ‐glutamyl) lysine isopeptide levels during cell growth: An enzymic and immunological study
A monoclonal antibody (MAb) 81D1c2, which recognizes the Nϵ(γ‐glutamyl) lysine isopeptide produced by the action of transglutaminase activity was prepared. Its reactivity towards the homologous… Expand
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gamma-Glutamyltranspeptidase activity in human breast lesions: an unfavourable prognostic sign.
The activity of gamma-glutamyltranspeptidase (gamma GT) (EC 2.3.2.2) was examined by histoenzymatic labelling on frozen sections derived from normal breast tissue, benign lesions and carcinomas. In… Expand
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Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells.
4-Methylthio-2-oxobutanoic acid is the direct precursor of methional, which is a potent inducer of apoptosis in a BAF3 murine lymphoid cell line which is interleukin-3 (IL3)-dependent. Cultures… Expand
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The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death.
Aldehyde dehydrogenases (ALDHs) are a family of several isoenzymes expressed in various tissues and in all subcellular fractions. In some tumours, there is an increase of ALDH activity, especially… Expand
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Synthesis of sodium salt of ortho-(difluoromethyl)phenyl-α-ketoside of N-acetylneuraminic acid : a mechanism-based inhibitor of Clostridium perfringens neuraminidase.
Abstract The title compound 7 was prepared in seven steps from N-acetylneuraminic acid and proven to be an enzyme-activated irreversible inhibitor of Clostridium perfringens neuraminidase. Title… Expand
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A thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene.
We have previously shown that methional, CH3SCH2CH2CHO, an endogeneous cellular aldehyderived by the oxidative decarboxylation of 4-methylthio-2-oxobutanoic acid (B), an intermediate in the… Expand
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Thérapie focalisée par micro-injections haute pression à l’aide d’un microtube implantable
Resume Ce travail a pour but de decrire une technique mini invasive de therapie focalisee de tumeurs basee sur des injections a haute pression a l’aide d’un microtube implantable. Le but est de… Expand
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