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Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors
To combat the LSC population selectively, a well-characterized ALDH inhibitor by the trivial name of dimethyl ampal thiolester (DIMATE) was assessed on sorted CD34+CD38− subpopulations from AML patients and healthy patients and spares healthy mouse hematologic cells.
α,β-Acetylenic amino thiolester inhibitors of aldehyde dehydrogenases 1&3: suppressors of apoptogenic aldehyde oxidation and activators of apoptosis.
The aim of this minireview is to recapitulate the evidence in the literature supporting a role for the aldehyde dehydrogenases (ALDH1, ALDH2 and ALDH3) in controlling the levels of 3 endogenous
Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells.
Evidence is provided for a fourth role for 4-methylthio-2-oxo-butanoate (MTOB) in apoptosis and for MASACoA, a substrate for one of the histone acyl transferases that could form amides via the CoA at one end and imines by its CHO group at the other, with amino groups on proteins.
Inhibition of type 5 adenovirus infectivity by periodate oxidation
Periodate oxidation of purified type 5 Adenovirus led to a mean loss of infectivity of 6.84 logs and one consequence of this in situ generation of formaldehyde is the formation of DNA-protein crosslinks.
Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells.
A role of cellular methional and malondialdehyde in apoptosis is supported, and the simultaneous presence of the methylthio group on the propanal moiety is essential for apoptosis to take place.