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Long-term stimulation by active epiretinal implants in normal and RCD1 dogs.
An epiretinal prosthesis, consisting of an extraocular microelectronic stimulator and an intraocular electrode array, was implanted in one eye of three blind and three sighted dogs. Three dogs (2Expand
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Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats.
Previous studies evaluating neural stem cells transplanted into the mature retina have demonstrated limited levels of graft-host integration and photoreceptor differentiation. The purpose of thisExpand
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A new model of experimental subretinal neovascularization in the rabbit.
Existing animal models of choroidal neovascularization (CNV) present several problems: they are hard to reproduce, they are inefficient, and the CNV created is not sustainable. The purpose of thisExpand
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Implantation of an inactive epiretinal poly(dimethyl siloxane) electrode array in dogs.
The aim of this study is to investigate the long-term, mechanical biocompatibility of a polymer microtechnology that can be used to position electrodes in close proximity to the retina.Expand
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Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo.
The purpose of this study is to characterize the co-expression of nestin--a neuroectodermal stem cell and a reactive glial marker-with various mature retinal cell markers in retinal progenitor cellsExpand
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Restoration of visual responses following transplantation of intact retinal sheets in rd mice.
PURPOSE To correlate the functional outcomes with histologic findings following transplantation of fetal retinal sheets in rd mice, and to investigate the mechanisms of visual function restoration.Expand
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Alternative culture conditions for isolation and expansion of retinal progenitor cells
Purpose. To investigate different in vitro model systems for retinal progenitor cell (RPC) isolation and expansion. Methods. RPCs were isolated from embryonic day (E) 17 Long Evans rat retinas. ThreeExpand
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Visual Functional Effects of Constant Blue Light in a Retinal Degenerate Rat Model
Retinal degenerative conditions increase susceptibility to light damage, but rapid retinal degeneration (RD) models show less susceptibility to cyclic dim light. We investigated whether constant blueExpand
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