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Long-term stimulation by active epiretinal implants in normal and RCD1 dogs.
- Dilek Güven, J. Weiland, +9 authors M. Humayun
- Medicine, Computer Science
- Journal of neural engineering
- 1 March 2005
An epiretinal prosthesis, consisting of an extraocular microelectronic stimulator and an intraocular electrode array, was implanted in one eye of three blind and three sighted dogs. Three dogs (2… Expand
Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats.
Previous studies evaluating neural stem cells transplanted into the mature retina have demonstrated limited levels of graft-host integration and photoreceptor differentiation. The purpose of this… Expand
A new model of experimental subretinal neovascularization in the rabbit.
Existing animal models of choroidal neovascularization (CNV) present several problems: they are hard to reproduce, they are inefficient, and the CNV created is not sustainable. The purpose of this… Expand
Implantation of an inactive epiretinal poly(dimethyl siloxane) electrode array in dogs.
The aim of this study is to investigate the long-term, mechanical biocompatibility of a polymer microtechnology that can be used to position electrodes in close proximity to the retina.… Expand
Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo.
- G. Qiu, M. Seiler, B. Thomas, K. Wu, Michael Radosevich, S. Sadda
- Biology, Medicine
- Experimental eye research
- 1 June 2007
The purpose of this study is to characterize the co-expression of nestin--a neuroectodermal stem cell and a reactive glial marker-with various mature retinal cell markers in retinal progenitor cells… Expand
Restoration of visual responses following transplantation of intact retinal sheets in rd mice.
PURPOSE To correlate the functional outcomes with histologic findings following transplantation of fetal retinal sheets in rd mice, and to investigate the mechanisms of visual function restoration.… Expand
Alternative culture conditions for isolation and expansion of retinal progenitor cells
Purpose. To investigate different in vitro model systems for retinal progenitor cell (RPC) isolation and expansion. Methods. RPCs were isolated from embryonic day (E) 17 Long Evans rat retinas. Three… Expand
Visual Functional Effects of Constant Blue Light in a Retinal Degenerate Rat Model
- B. Thomas, M. Seiler, +6 authors S. Sadda
- Chemistry, Medicine
- Photochemistry and photobiology
- 28 March 2007
Retinal degenerative conditions increase susceptibility to light damage, but rapid retinal degeneration (RD) models show less susceptibility to cyclic dim light. We investigated whether constant blue… Expand
Phenotypic characteristics of retinal progenitor cells isolated from hPAP–positive rat embryonic retina
BDNF microsphere treatment increases functional effects of retinal transplants