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Integrative Toxicopathological Evaluation of Aflatoxin B1 Exposure in F344 Rats
TLDR
It is demonstrated that liver GST-P+ cells and foci are sensitive biomarkers for AFB1 toxic effect and correlated with bile duct proliferation and biochemical alterations in F344 rats. Expand
Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma.
TLDR
The incidence and level of AF and PAH exposure were less than those observed in a high-risk population; however, participants consuming higher amounts of foods prone to AF contamination may be more vulnerable to exposure and interactions with other environmental/biological factors. Expand
Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation
TLDR
Modulation of MEK/ERK-dependent Bim and Mcl-1 degradation critically mediates sensitivity and resistance of EGFR-mutant NSCLC cells to AZD9291 and hence is an effective strategy to overcome acquired resistance to AZd9291. Expand
Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats
TLDR
It is indicated that repeated AFB1 exposure promotes inflammatory responses by regulating cytokine expression and suggests the involvement of an inflammatory response upon repeated exposure. Expand
Integrative toxicological evaluation of aflatoxin B1 exposure in Fischer 344 rats and biomarker based exposure assessment of aflatoxin B1 in human populations
TLDR
The results provide an integrative toxicopathological evaluation of AFB1 exposure in F344 rats and may facilitate human aflatoxin exposure assessment and improve the understanding of how AFB1 can affect immune response. Expand
Human papillomavirus 16 oncoprotein regulates the translocation of β‐catenin via the activation of epidermal growth factor receptor
TLDR
This study investigated whether β‐catenin is regulated by the HPV oncoprotein and contributes to OPSCC metastasis. Expand
Mitigation of Oxidative Damage by Green Tea Polyphenols and Tai Chi Exercise in Postmenopausal Women with Osteopenia
TLDR
GTP and TC interventions were effective strategies of reducing the levels of oxidative stress, a putative mechanism for osteoporosis in postmenopausal women, and more importantly, working in an additive manner, which holds the potential as alternative tools to improve bone health in this population. Expand
Physiologically based toxicokinetics of serum aflatoxin B1-lysine adduct in F344 rats.
TLDR
The toxicokinetic evaluation of serum AFB-Lys adduct in F344 rats using a physiologically based pharmacokinetic model and robust statistical modeling analysis provided a firm and clear understanding of the toxicokinetics of this biomarker. Expand
Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma
TLDR
The authors explored the prognostic significance of heregulin/HER3 expression in patients with oropharyngeal squamous cell carcinoma (OPSCC), taking into account other HER family members as well as p16 status. Expand
Overcoming acquired resistance of epidermal growth factor receptor‐mutant non–small cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat
TLDR
LBH589 (panobinostat), a clinically used histone deacetylase inhibitor, is identified as a potential agent in overcoming osimertinib resistance, and could play a key role in overcoming acquired resistance. Expand
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