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Microsatellite Instability and Colorectal Cancer Prognosis
Purpose: Many studies have evaluated the role of high levels of microsatellite instability (MSI) as a prognostic marker and predictor of the response to chemotherapy in colorectal cancer (CRC);… Expand
Muir-Torre syndrome is an autosomal-dominant skin condition of genetic origin, characterised by tumours of the sebaceous gland or keratoacanthoma that are associated with visceral malignant diseases.… Expand
Biomarkers associated with COVID-19 disease progression
- G. Ponti, M. Maccaferri, C. Ruini, A. Tomasi, T. Ozben
- Critical reviews in clinical laboratory sciences
- 5 June 2020
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a scientific, medical, and social challenge. The complexity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is… Expand
Identification of Muir–Torre syndrome among patients with sebaceous tumors and keratoacanthomas
The Muir–Torre syndrome (MTS) is an autosomal‐dominant genodermatosis characterized by the presence of sebaceous gland tumors, with or without keratoacanthomas, associated with visceral malignancies.… Expand
Molecular Genetic Alterations and Clinical Features in Early-Onset Colorectal Carcinomas and Their Role for the Recognition of Hereditary Cancer Syndromes
- L. Losi, C. Gregorio, +12 authors M. P. Leòn
- The American Journal of Gastroenterology
- 1 October 2005
OBJECTIVES:Colorectal cancer (CRC) occurs rarely in young individuals (<45 yr) and represents one of the criteria for suspecting hereditary cancer families. In this study we evaluated clinical… Expand
Reticular grey‐blue areas of regression as a dermoscopic marker of melanoma in situ
- S. Seidenari, C. Ferrari, +6 authors G. Pellacani
- The British journal of dermatology
- 1 August 2010
Background By dermoscopy, regression structures are substantially defined by the presence of white and blue areas in the lesion image. As fibrosis and melanosis are often seen in malignant melanoma… Expand
Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes.
- G. Ponti, G. Pellacani, S. Seidenari, A. Pollio, U. Muscatello, A. Tomasi
- Critical reviews in oncology/hematology
- 1 March 2013
Characteristic skin neoplasms are associated with a large number of hereditary tumor syndromes and their knowledge and early detection may facilitate the diagnosis of the underlying malignancies. We… Expand
Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis.
BACKGROUND & AIMS MYH-associated polyposis is a recently described, autosomal-recessive disease characterized by multiple colorectal adenomas and cancer. There are only few immunohistochemical… Expand
Ameloblastoma: a neglected criterion for nevoid basal cell carcinoma (Gorlin) syndrome
Ameloblastomas are considered to be aggressive and locally invasive neoplasms derived from odontogenic epithelium with a tendency for recurrence and bone destruction. Although the relationship… Expand
Oral mucosal stigmata in hereditary-cancer syndromes: From germline mutations to distinctive clinical phenotypes and tailored therapies.
Numerous familial tumor syndromes are associated with distinctive oral mucosal findings, which may make possible an early diagnosis as an efficacious marker for the risk of developing visceral… Expand