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- Publications
- Influence
Drug Disposition in Cystic Fibrosis
- E. Rey, J. Tréluyer, G. Pons
- Medicine
- Clinical pharmacokinetics
- 1 October 1998
There are many pathological changes in patients with cystic fibrosis (CF) which can lead to alterations in drug disposition.Although, in patients with CF, the extent of drug absorption varies widely… Expand
Vigabatrin. Clinical pharmacokinetics.
Vigabatrin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacological… Expand
[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)].
- T. N. Thanh, C. Chiron, +4 authors O. Dulac
- Medicine
- Archives de pediatrie : organe officiel de la…
- 2002
OBJECTIVE
To describe the long term efficacy and tolerance of stiripentol associated with valproate and clobazam in an exhaustive cohort of patients with severe myoclonic epilepsy of infancy… Expand
Pharmacokinetics and toxicity of docetaxel: Role of CYP3A, MDR1, and GST polymorphisms
- A. Tran, V. Jullien, +7 authors J. Tréluyer
- Biology, Medicine
- Clinical pharmacology and therapeutics
- 1 June 2006
Patients initiating docetaxel chemotherapy were genotyped for CYP3A4, CYP3A5, MDR1, GSTM1, GSTT1, GSTM3, and GSTP1 to identify variability factors of docetaxel pharmacokinetics and toxicity.
Maternal-Fetal Transfer and Amniotic Fluid Accumulation of Nucleoside Analogue Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pregnant Women
- H. Chappuy, J. Treluyer, +6 authors L. Mandelbrot
- Medicine
- Antimicrobial Agents and Chemotherapy
- 1 November 2004
ABSTRACT This study was performed to investigate placental transfer of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and their concentrations in amniotic fluid when given to human… Expand
Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity.
- O. Mir, J. Alexandre, +4 authors F. Goldwasser
- Medicine
- Annals of oncology : official journal of the…
- 1 April 2009
BACKGROUND
Glutathione-S-transferases (GST) regulate the cellular response to oxidative stress. We previously highlighted the importance of oxidative stress in taxane toxicity and therefore… Expand
The triangular test to assess the efficacy of metoclopramide in gastroesophageal reflux
- E. Bellissant, J. Duhamel, M. Guillot, A. ParienTe-khayaT, G. Olive, G. Pons
- Medicine
- Clinical pharmacology and therapeutics
- 1 March 1997
Sequential methods are particularly interesting when recruitment is difficult because they may allow a study to be stopped early while maintaining type I and II error rates.
A randomized, double‐blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children
Summary— Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double‐blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of… Expand
Pharmacokinetic Optimisation of Benzodiazepine Therapy for Acute Seizures
- E. Rey, J. Treluyer, G. Pons
- Medicine
- 1 June 1999
All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for diazepam (<2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) and lorazepam (up… Expand
Experimental designs for small randomised clinical trials: an algorithm for choice
- C. Cornu, B. Kassai, +13 authors P. Nony
- Computer Science, Medicine
- Orphanet Journal of Rare Diseases
- 25 March 2013
TLDR