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Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases.
Energy regulation (EnR) is most important for homoeostatic regulation of physiological processes. Neuroendocrine pathways are involved in EnR. We can separate factors that provide energy-rich fuels… Expand
Platelet activation in embolic and preembolic status of patients with nonrheumatic atrial fibrillation.
STUDY OBJECTIVE Information on platelet activation possibly associated with a preembolic or embolic status in nonrheumatic atrial fibrillation (AF) with special regard to the role of platelet… Expand
Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis.
- P. Haerle, G. Pongratz, C. Weidler, R. Buettner, J. Schoelmerich, R. Straub
- Annals of the rheumatic diseases
- 1 July 2004
BACKGROUND Hypoandrogenicity is common in obesity and in chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Adrenal androgens such as… Expand
A patient with Pfeifer-Weber-Christian Disease - Successful Therapy with Cyclosporin A: case report
- G. Pongratz, B. Ehrenstein, W. Hartung, J. Schoelmerich, M. Fleck
- BMC musculoskeletal disorders
- 27 January 2010
BackgroundPfeifer-Weber-Christian disease (PWCD) is a rare inflammatory disorder of the subcutaneous fatty tissue. The diagnosis and therapy of this rare type of panniculitis is still controversial… Expand
Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis.
- G. Pongratz, J. Lindner, S. Modrow, S. Schimanski, J. Schoelmerich, M. Fleck
- Journal of internal medicine
- 1 September 2009
We, here, report the case of a parvovirus B19 infection in an immunocompetent male patient presenting with acute hepatitis and polyarthritis. To follow the course of infection, we used a previously… Expand
The sympathetic nervous response in inflammation
Over the past decades evidence has accumulated clearly demonstrating a pivotal role for the sympathetic nervous system (SNS) and its neurotransmitters in regulating inflammation. The first part of… Expand
The Level of IgE Produced by a B Cell Is Regulated by Norepinephrine in a p38 MAPK- and CD23-Dependent Manner1
- G. Pongratz, J. McAlees, D. Conrad, R. S. Erbe, K. Haas, V. Sanders
- Medicine, Biology
- The Journal of Immunology
- 1 September 2006
Although the causes of asthma vary, the severity of the disease correlates with the level of IgE produced. In this study we show that mice produced less IgE when they were depleted of the… Expand
The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis
Background As previously shown, the sympathetic nervous system (SNS) shows proinflammatory activity during initiation of arthritis but is anti-inflammatory in established collagen-induced arthritis… Expand
Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion.
OBJECTIVE New insights into the role of tumor necrosis factor (TNF) in the pathogenesis of rheumatoid arthritis (RA) have expanded our understanding about the possible mechanisms by which anti-TNF… Expand
Via β-adrenoceptors, stimulation of extrasplenic sympathetic nerve fibers inhibits lipopolysaccharide-induced TNF secretion in perfused rat spleen
- M. Kees, G. Pongratz, F. Kees, J. Schoelmerich, R. Straub
- Journal of Neuroimmunology
- 1 December 2003
Using a spleen slice microsuperfusion technique in mice, we have previously characterized the role of norepinephrine (NE) and other neurotransmitters for sympathetic modulation of IL-6 and TNF… Expand