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Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial β-glucosidases (LPH andCBG), indicating a role of human LPH and CBG from small intestine in flavonoids absorption and metabolism. Expand
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
The ability of LPH to deglycosylate dietary (iso)flavonoid glycosides suggests a possible role for this enzyme in the metabolism of these biologically active compounds. Expand
Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.
The results show that food components have the potential to modify drug metabolism in the human enterocyte in vivo very rapidly. Expand
Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway.
Quercetin derived from quercETin-3-glucoside passes across the small intestinal epithelium more rapidly than free quercet in aglycone, and interacts with the sodium-dependent glucose transporter. Expand
Properties of Quercetin Conjugates: Modulation of LDL Oxidation and Binding to Human Serum Albumin
The data show that flavonoid intestinal and hepatic metabolism have profound effects on ability to inhibit LDL oxidation and to bind to human albumin, in comparison to free flavonoids and other quercetin conjugates. Expand
Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora
Results show that chlorogenic acid ingested by humans is most likely cleaved into caffeic acid and quinic acid by an esterase enzyme(s) provided by the colonic microflora. Expand
Human metabolic pathways of dietary flavonoids and cinnamates.
The biochemistry of the uptake and metabolic route of two groups of plant phenolics, the flavonols and hydroxycinnamates are examined, which contribute to the health benefits of a diet rich in fruit and vegetables. Expand
Antioxidant properties of flavonol glycosides from green beans.
The compounds described herein demonstrate the antioxidant activity of the flavonols present in green beans and indicate the effect on antioxidants activity of sugar substitutions in the phenolic C ring. Expand
Antioxidant properties of catechins and proanthocyanidins: effect of polymerisation, galloylation and glycosylation.
A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography from grape seed, apple skin, lentil and almond flesh and scavenging of the radical cation of 2,2'-azinobis(3-ethyl-benzothiazoline-6-sulphonate) relative to the water-soluble vitamin E analogue Trolox C was assessed. Expand
Antioxidant activities of extracts from five anti-viral medicinal plants.
The antioxidant activities of five medicinal plants (Ampelopsis sinica, Ampelopsis humiliforlia var. heterophylla, Potentilla freyniana, Selaginella labordei and Chrysanthemum multiflorum), used inExpand