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A dose-comparison trial of topiramate as monotherapy in recently diagnosed partial epilepsy
Objective: To evaluate topiramate as monotherapy in adults and children with recently diagnosed, localization-related epilepsy, comparing two dosages of topiramate in a multicenter, randomized,Expand
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A double-blind, randomized trial of topiramate in Lennox–Gastaut syndrome
Objective: To evaluate the efficacy and safety of topiramate as adjunctive therapy for Lennox–Gastaut syndrome in a multicenter, double-blind, placebo-controlled trial. Background: ConventionalExpand
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A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures
Background and Objective: Topiramate is effective as adjunctive treatment of partial-onset seizures in adults. The efficacy and safety of topiramate as adjunctive therapy for the treatment of primaryExpand
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Consistency in Concave Regression
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Topiramate Monotherapy for Partial Onset Seizures
Summary: Purpose: Evaluation of topiramate (TPM) as monotherapy in patients with uncontrolled partial onset seizures.
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Double‐Blind, Placebo‐Controlled Trial of Topiramate (600 mg Daily) for the Treatment of Refractory Partial Epilepsy
Summary: Purpose: We wished to evaluate adjunctive therapy for partial‐onset seizures with topiramate (TPM) for efficacy and safety in a double‐blind, placebo‐controlled, randomized, parallel‐groupExpand
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Double‐Blind, Placebo‐Controlled Trial of Topiramate as Add‐on Therapy in Patients with Refractory Partial Seizures
Summary: In a double‐blind, randomized, parallel‐group trial, we compared topiramate (TPM) with placebo as addon therapy in patients with refractory partial epilepsy. TPM was titrated either to theExpand
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A double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children
Objective: To evaluate the efficacy and safety of topiramate 6 mg/kg/day in children (age 2 to 16 years) as adjunctive therapy for uncontrolled partial-onset seizures with or without secondarilyExpand
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A Multicenter, Randomized Clinical Study to Evaluate the Effect on Cognitive Function of Topiramate Compared with Valproate as Add‐On Therapy to Carbamazepine in Patients with Partial‐Onset Seizures
Summary: Purpose: This study compares the cognitive effects of topiramate (TPM) with those of valproate (VPA) using efficacious doses of each drug when used as adjunctive therapy to carbamazepineExpand
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