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The effects of purine nucleosides on 5-phosphoribosylpyrophosphate (PP-ribose-P) synthesis were investigated in human erythrocytes in vitro. Previous observations have shown an increase of… Continue Reading
Male CD-strain rats (100--125 g) received fenitrothion by oral gavage (2.5, 5.0, 10.0 or 20.0 mg/kg/day) for 30 consecutive days. Control animals received equivalent volumes of taurocholate vehicle.… Continue Reading
Abstract Hypoxanthine (or guanine) phosphoribosyltransferase (EC 126.96.36.199) and adenine phosphoribosyltransferase (EC 188.8.131.52) activities have been evaluated in mouse brain, liver and muscle as a… Continue Reading
The intracellular concentration of PP-ribose-P is a balance between its formation and its utilization. Purine nucleosides stimulate PP-ribose-P formation in mammalian cells when inorganic phosphate… Continue Reading