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A key role of leptin in the control of regulatory T cell proliferation.
We report here that leptin can act as a negative signal for the proliferation of human naturally occurring Foxp3(+)CD4(+)CD25(+) regulatory T (T(reg)) cells. Freshly isolated T(reg) cells producedExpand
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Detection and Characterization of CD133+ Cancer Stem Cells in Human Solid Tumours
Background Osteosarcoma is the most common primary tumour of bone. Solid tumours are made of heterogeneous cell populations, which display different goals and roles in tumour economy. A rather smallExpand
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The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer.
OBJECTIVE Emerging evidence suggests that specific sub-populations of cancer cells with stem cell characteristics within the bulk of tumours are implicated in the pathogenesis of heterogeneousExpand
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A New Population of Human Adult Dental Pulp Stem Cells: A Useful Source of Living Autologous Fibrous Bone Tissue (LAB)
Stem cells, derived from human adult dental pulp of healthy subjects 30‐45 years of age, were cultured, and cells were selected using a FACSorter. A new c‐kit+/CD34+/CD45− cell population of stromalExpand
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TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction
Metastasis is the leading cause of death by cancer. Non-small-cell lung cancer (NSCLC) represents nearly 85% of primary malignant lung tumours. Recent researches have demonstrated thatExpand
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An approachable human adult stem cell source for hard‐tissue engineering
Stem cells were obtained from deciduous dental pulp of healthy subjects, aged 6–10 years. This stem cell population was cultured, expanded, and specifically selected, detecting using a FACsorter,Expand
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Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis
TRAP-1 is a mitochondrial heat shock protein (HSP), recently identified in Saos-2 osteosarcoma cells adapted to mild oxidative stress induced by diethylmaleate (DEM). TRAP-1 mRNA expression isExpand
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Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement
Adult mesenchymal stem cells, such as dental pulp stem cells, are of great interest for cell‐based tissue engineering strategies because they can differentiate into a variety of tissue‐specificExpand
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CD133: to be or not to be, is this the real question?
CD133 (promini-1) is a member of the transmembrane glycoprotein family, was initially described as a specific marker to select human hematopoietic progenitor cells. Then, it was recognised asExpand
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Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo
This study aimed to identify, isolate, and characterize cancer stem cells from human primary sarcomas. We performed cytometric analyses for stemness and differentiation antigens, including CD29,Expand
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