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Factor deficiencies in pregnancy.
Pregnancy, childbirth, and the puerperium are hemostatically challenging to women with bleeding disorders. This article provides general recommendations for the management of pregnant women withExpand
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Sample conditions determine the ability of thrombin generation parameters to identify bleeding phenotype in FXI deficiency.
Individuals with Factor XI (FXI) deficiency have a variable bleeding tendency that does not correlate with FXI:C levels or genotype. Comparing a range of sample conditions, we tested whether theExpand
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Factor XI‐related thrombosis and the role of concentrate treatment in factor XI deficiency
The management of inherited factor XI (FXI) deficiency poses problems because of the poor relationship between the measured FXI level and bleeding tendency. In addition, treatment of FXI-deficientExpand
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Evaluation of the use of global haemostasis assays to monitor treatment in factor XI deficiency
Previous guidelines recommend that FXI:C levels should be used to monitor FXI replacement in factor XI (FXI) deficiency. However, FXI:C levels do not correlate with bleeding tendency in this disorderExpand
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Evaluation of the use of rotational thromboelastometry in the assessment of FXI deficency
The absence of a reliable clinical test to predict bleeding tendency leaves factor XI (FXI)‐deficient individuals at risk of overtreatment or under treatment.
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In vitro comparison of the effect of two factor XI (FXI) concentrates on thrombin generation in major FXI deficiency
Bleeding risk in factor XI (FXI) deficiency following surgery may be reduced by treatment with either of two FXI concentrates, but indications for their use are unclear and treatment has beenExpand
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Contact Activation Inhibition and Platelet Rich Plasma Are Required in Order to Differentiate Bleeders from Non-Bleeders in FXI Deficiency Using the Thrombin Generation Assay
Introduction : FXI deficiency is characterised by a variable bleeding tendency. No clear correlation exists between bleeding and either FXI:C level or genotype. Some patients with major FXIExpand
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Two Factor XI Concentrates Correct Impaired Thrombin Generation in Major FXI Deficiency but Are Not Equivalent in Their Effect
Introduction: Factor XI (FXI) deficiency is an autosomally inherited bleeding disorder characterised by an increased risk of excessive bleeding following trauma or surgery. However, considerableExpand
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Jordan’s anomaly in a case of Chanarin–Dorfman syndrome
A 22–month–old boy presented with hepatomegaly, ichthyosis and asthma. Blood tests were normal except for a raised creatine kinase (CK) of 1077 iu/l, an elevated alanine transaminase of 216 iu/l andExpand
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Thrombin generation measured in platelet rich plasma with contact activation inhibition identifies bleeding phenotype in FXI deficiency. Abstract Individuals with FXI deficiency have a variable
Individuals with FXI deficiency have a variable bleeding tendency which does not correlate with FXI:C levels or genotype. Comparing a range of sample conditions we tested whether the thrombinExpand