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PDZ‐mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
TLDR
Interactions with PDZ proteins determine the polarized surface localization of target proteins by means of retention and not targeting mechanisms, and may act as a sort of membrane protein sorting machinery which, by recognizing retention signals (the PDZ target sequences), prevents protein internalization. Expand
The GLT‐1 and GLAST Glutamate Transporters Are Expressed on Morphologically Distinct Astrocytes and Regulated by Neuronal Activity in Primary Hippocampal Cocultures
TLDR
The data indicate that soluble factors dependent on neuronal activity play a major regulating role in hippocampal cocultures and soluble factors in neuronal‐conditioned media prevented the down‐regulation of the GLT‐1 and GLAST proteins. Expand
Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture.
TLDR
Data suggest that epithelial cells and hippocampal neurons localize these proteins by different mechanisms, which contrast with those made for the vesicular stomatitis virus and the influenza glycoproteins, which are polarized in both epithelial and neuronal cells. Expand
The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis1
TLDR
The purinergic activation of microglia may constitute a new route involved in the progression of ALS to be exploited to potentially halt the disease. Expand
Mammalian LIN‐7 PDZ proteins associate with β‐catenin at the cell–cell junctions of epithelia and neurons
TLDR
It is reported here that mammalian LIN‐7 PDZ proteins form a complex with cadherin and β‐catenin in epithelia and neurons and suggests the mechanism by which β‐ catenin mediates the organization of the junctional domain. Expand
Invasive behaviour of glioblastoma cell lines is associated with altered organisation of the cadherin-catenin adhesion system.
TLDR
Results identify the LIN-7 PDZ protein as a marker of cell adhesion maturity and cell invasion and indicate that instability and disorganisation of cadherin-mediated junctions rather than reduced expression of cadhersin-catenin system components are required to promote migration and invasiveness in glioblastoma cell lines. Expand
The axonal gamma-aminobutyric acid transporter GAT-1 is sorted to the apical membranes of polarized epithelial cells.
TLDR
It would appear that despite their high degree of homology, the BGT-1 and GAT-1 transporters manifest sorting signals which specify their targeting to distinct cell surface domains, which may be similar to that which mediates apical localization in epithelia. Expand
Two transcripts encode rat cytochrome b5 reductase.
TLDR
Results of Southern blot analysis were consistent with the hypothesis that a single gene codes for the soluble and membrane-bound forms of the reductase, present in erythrocytes and liver, respectively. Expand
Localization and biosynthesis of NADH-cytochrome b5 reductase, an integral membrane protein, in rat liver cells. II. Evidence that a single enzyme accounts for the activity in its various subcellular
TLDR
The hypothesis that NADH-cytochrome b5 reductase in its various subcellular locations is molecularly identical is supported. Expand
A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes
TLDR
The results indicate that myristoylated reductase localizes to ER and mitochondria by different mechanisms, and reveal a novel role for myristic acid in protein targeting. Expand
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