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Lung Infections Associated with Cystic Fibrosis
SUMMARY While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is now recognized as a single disease whose diverse symptoms stem from the wide tissue distributionExpand
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Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist.
Pseudomonas aeruginosa is an ubiquitous pathogen capable of infecting virtually all tissues. A large variety of virulence factors contribute to its importance in burn wounds, lung infection and eyeExpand
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Intraspecific Diversity of Yersinia pestis
SUMMARY Increased interest in the pathogenic potential of Yersinia pestis has emerged because of the potential threats from bioterrorism. Pathogenic potential is based on genetic factors present in aExpand
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Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections
Clinical isolates of Staphylococcus aureus can express biofilm phenotypes promoted by the major cell wall autolysin and the fibronectin-binding proteins or the icaADBC-encoded polysaccharideExpand
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Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains.
Twenty-six Pseudomonas aeruginosa strains from patients with cystic fibrosis were typed by the Fisher immunotyping scheme. Only 6 strains were agglutinated by a single typing serum, whereas 15Expand
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Immunochemical Properties of the Staphylococcal Poly-N-Acetylglucosamine Surface Polysaccharide
ABSTRACT Staphylococcus aureus and Staphylococcus epidermidis often elaborate adherent biofilms, which contain the capsular polysaccharide-adhesin (PS/A) that mediates the initial cell adherence toExpand
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Role of Mutant CFTR in Hypersusceptibility of Cystic Fibrosis Patients to Lung Infections
Cystic fibrosis (CF) patients are hypersusceptible to chronic Pseudomonas aeruginosa lung infections. Cultured human airway epithelial cells expressing the ΔF508 allele of the cystic fibrosisExpand
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Salmonella typhi uses CFTR to enter intestinal epithelial cells
Homozygous mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF). In the heterozygous state, increased resistance to infectious diseases may maintainExpand
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ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.
Overproduction of the exopolysaccharide alginate and conversion to a mucoid phenotype in Pseudomonas aeruginosa are markers for the onset of chronic lung infection in cystic fibrosis (CF). AlginateExpand
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Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.
The roles of the Pseudomonas aeruginosa proteases LasB (elastase) and LasA and the transcriptional activator LasR, which regulates the expression of these proteases, were evaluated in a murine modelExpand
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