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Solid lipid microparticles: formulation, preparation, characterisation, drug release and applications
TLDR
The properties of solid lipid microparticles (SLMs): a promising drug carrier system that has been until now rather unexploited are detailed. Expand
Application of Supercritical Carbon Dioxide for the Preparation of a Piroxicam-β-Cyclodextrin Inclusion Compound
TLDR
Supercritical carbon dioxide may prove to be a novel useful complexation method of drugs into β-cyclodextrin by improving the solubility and stability of piroxicam in supercritical CO2. Expand
Nanocarriers for the treatment of glioblastoma multiforme: Current state-of-the-art.
TLDR
The features of blood-brain barrier, and its anatomical changes with different stages of tumor growth are described, and various strategies to improve brain drug delivery i.e. tight junction opening, chemical modification of the drug, efflux transporter inhibition, convection-enhanced delivery and drug delivery nanosystems are discussed. Expand
Solid lipid microparticles as a sustained release system for pulmonary drug delivery.
TLDR
SA in vitro release study from SLMs showed that the release rate increased with SA loading but remained in every case lower than the dissolution rate of pure SA. Expand
Betamethasone-in-cyclodextrin-in-liposome: the effect of cyclodextrins on encapsulation efficiency and release kinetics.
TLDR
It is shown that release kinetics are directly correlated with encapsulation efficiency, which is closely related to betamethasone concentration in cyclodextrin complex solution, which was proved by the comparison of phase solubility diagrams of both betamETHasone and cholesterol. Expand
Skin penetration behaviour of liposomes as a function of their composition.
TLDR
This study showed that liposomes do not stay intact when they penetrate the deepest layers of the skin, as shown in ex vivo diffusion experiments using pig ear skin. Expand
Systematic characterization of oil-in-water emulsions for formulation design.
TLDR
Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared and 10 experiments were performed to characterize them to find out which tests should be carried out to assess efficiently the stability and the properties of an emulsified preparation. Expand
Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes.
TLDR
The purpose of the present study was to investigate the interaction of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide. Expand
Comparison of chitosan/siRNA and trimethylchitosan/siRNA complexes behaviour in vitro.
TLDR
Chitosan and TMC complexes present some characteristics favourable for siRNA delivery, such as ability to integrate siRNA into small discrete particles or low toxicity of the complexes, which highlights the importance of complexes stability in physiological environment for si RNA transfection purposes. Expand
Theoretical and experimental investigations on miconazole/cyclodextrin/acid complexes: molecular modeling studies.
TLDR
AM1 approximate molecular orbital calculations have been performed on several cyclodextrins complexes with miconazole and acidic compounds (maleic, fumaric and L-tartaric acids) as partners and clearly demonstrates that the structure of both cyclodesxtrin and acid plays a key-role in the formation of inclusion complexes. Expand
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