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Role of potassium ion channels in detrusor smooth muscle function and dysfunction
- G. Petkov
- MedicineNature Reviews Urology
This Review summarizes the current state of knowledge of the functional role of K+ channels in DSM in health and disease, with special emphasis on current advancements in the field.
Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology.
- G. Petkov
- Chemistry, MedicineAmerican journal of physiology. Regulatory…
- 15 September 2014
Modulation of UBSM BK channels can occur by directly or indirectly targeting their regulatory mechanisms, which has the potential to provide novel therapeutic approaches for bladder dysfunction, such as overactive bladder and detrusor underactivity.
Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle.
- G. Petkov, A. Bonev, T. Heppner, R. Brenner, R. Aldrich, M. Nelson
- MedicineThe Journal of physiology
The results indicate that the beta1-subunit, by modulating BK channel activity, plays a significant role in the regulation of phasic contractions of the urinary bladder.
Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel.
- G. Herrera, M. Pozo, +4 authors M. Nelson
- Chemistry, MedicineThe Journal of physiology
- 15 September 2003
The ability to examine bladder function in mice in which SK3 channel expression is selectively altered reveals that these channels have a significant role in the control of non-voiding contractions in vivo.
Pharmacological Activation of Small Conductance Calcium-Activated Potassium Channels with Naphtho[1,2-d]thiazol-2-ylamine Decreases Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
- S. Parajuli, R. Soder, K. Hristov, G. Petkov
- Chemistry, MedicineJournal of Pharmacology and Experimental…
- 1 January 2012
It is observed that SK channels, but not IK channels, mediate SKA-31 effects in guinea pig DSM and therefore may provide a novel therapeutic approach for controlling bladder dysfunction.
Molecular Expression and Pharmacological Evidence for a Functional Role of Kv7 Channel Subtypes in Guinea Pig Urinary Bladder Smooth Muscle
Kv7 channel subtype-specific antibodies and α-smooth muscle actin provide potential novel therapeutic targets for urinary bladder dysfunction and their pharmacological modulation can control DSM contractility and excitability.
Neurogenic Detrusor Overactivity Is Associated with Decreased Expression and Function of the Large Conductance Voltage- and Ca2+-Activated K+ Channels
- K. Hristov, Serge A. Y. Afeli, S. Parajuli, Qiuping Cheng, E. Rovner, G. Petkov
- Chemistry, MedicinePloS one
- 5 July 2013
The novel finding that NDO is associated with decreased DSM BK channel expression and function leading to increased DSM excitability and contractility is revealed.
β1‐Subunit of the Ca2+‐activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle
1 The large‐conductance calcium‐activated potassium (BK) channel plays an important role in controlling membrane potential and contractility of urinary bladder smooth muscle (UBSM). These channels…
Large-conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function.
- K. Hristov, Muyan Chen, Whitney F. Kellett, E. Rovner, G. Petkov
- Biology, MedicineAmerican journal of physiology. Cell physiology
- 1 October 2011
The results indicate that BK channels are fundamental regulators of DSM excitability and contractility and may represent new targets for pharmacological or genetic control of urinary bladder function in humans.
Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle.
It is identified that the bladder smooth muscle BK channel has a distinctive architecture involving pore forming BKalpha and regulatory BKbeta1/beta4 and new drugs targeting specific BKChannel subunits in human bladder smoother muscle may prove useful for overactive bladder.