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Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer.
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control. Expand
Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91-11.
Laryngectomy following organ preservation treatment is associated with acceptable morbidity and local-regional control is excellent for this group of patients, and survival following salvage TL was not influenced by the initial organ Preservation treatment. Expand
Locoregionally advanced head and neck cancer treated with primary radiotherapy: a comparison of the addition of cetuximab or chemotherapy and the impact of protocol treatment.
A single-institution retrospective review of patients treated with ExRT or ChRT for locoregional control, distant metastasis-free survival, disease-specific survival, and overall survival found no significant differences. Expand
Treatment of recurrent head and neck cancer with 5-fluorouracil, hydroxyurea, and reirradiation.
Reirradiation with 5-fluorouracil and hydroxyurea is a well tolerated outpatient treatment program for patients with recurrent and previous irradiated head and neck cancer that produces a high response rate and can provide significant palliation of symptoms. Expand
Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck.
Short-course clindamycin is as effective in preventing wound infections after free-flap surgery for head and neck ablative defects and no other independent predictors of wound complications emerged in this series of patients. Expand
Molecular Differences in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Major Salivary Glands
To determine whether MEC and ACC have different molecular characteristics, the expression of erbB‐2, erBB‐3, epidermal growth factor receptor (EGFR), and transforming growth factor‐α (TGF‐α), important molecular features in other malignancies were examined. Expand
Primary versus delayed tracheoesophageal puncture for laryngopharyngectomy with free flap reconstruction
To determine whether postoperative complication rates and speech outcomes differ between patients undergoing primary versus secondary tracheoesophageal puncture following total laryngectomy with freeExpand
Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers.
Preclinical work serves as important support for the ongoing clinical investigation of C225 and radiotherapy for patients with head and neck carcinomas by indirectly linking C225/radiation-induced regulation of STAT-3 protein to apoptosis. Expand
Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector.
An adenoviral vector genetically modified to contain a peptide within the HI loop of the fiber protein as a means to alter viral tropism allowed enhanced gene transfer efficiencies to SCCHN tumor cells and could achieve preferential augmentation of gene transfer in tumor cells compared with normal cells. Expand
Free Tissue Transfer to Manage Salvage Laryngectomy Defects After Organ Preservation Failure
Salvage laryngectomy to treat organ preservation failures results in significantly higher local wound complications, and it is hypothesize that even when sufficient mucosa is present to close the defect primarily, introduction of vascularized tissue to open the defect may improve outcomes. Expand