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Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections
How sister kinetochores attach to microtubules from opposite spindle poles during mitosis (bi-orientation) remains poorly understood. In yeast, the ortholog of the Aurora B-INCENP protein kinaseExpand
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The Bub2p spindle checkpoint links nuclear migration with mitotic exit.
Bfa1p and Bub2p are spindle checkpoint proteins that likely have GTPase activation activity and are associated with the budding yeast spindle pole body (SPB). Here, we show that Bfa1p and Bub2p bindExpand
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Modes of spindle pole body inheritance and segregation of the Bfa1p–Bub2p checkpoint protein complex
Yeast spindle pole bodies (SPBs) duplicate once per cell cycle by a conservative mechanism resulting in a pre‐existing ‘old’ and a newly formed SPB. The two SPBs of yeast cells are functionallyExpand
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Kin4 kinase delays mitotic exit in response to spindle alignment defects.
For many polarized cells, it is critical that the mitotic spindle becomes positioned relative to the polarity axis. This is especially important in yeast, where the site of cytokinesis isExpand
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The spindle pole body component Spc97p interacts with the γ‐tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication
Previously, we have shown that the γ‐tubulin Tub4p and the spindle pole body component Spc98p are involved in microtubule organization by the yeast microtubule organizing centre, the spindle poleExpand
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Separase Regulates INCENP-Aurora B Anaphase Spindle Function Through Cdc14
The inner centromere-like protein (INCENP) forms a complex with the evolutionarily conserved family of Aurora Bkinases. The INCENP-Aurora complex helps coordinate chromosome segregation, spindleExpand
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The spindle pole body component Spc98p interacts with the gamma‐tubulin‐like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.
Tub4p is a novel tubulin found in Saccharomyces cerevisiae. It most resembles gamma‐tubulin and, like it, is localized to the yeast microtubule organizing centre, the spindle pole body (SPB). In thisExpand
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Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast
The mitotic-exit network (MEN) is a signaling pathway that is essential for the coordination of mitotic exit and cytokinesis. Whereas the role of the MEN in mitotic exit is well established, theExpand
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Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery
Centrins are calmodulin-like proteins that function in the duplication of microtubule-organizing centres. Here we describe a new function of the yeast centrin Cdc31. We show that overproduction of aExpand
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Interaction of the yeast γ‐tubulin complex‐binding protein Spc72p with Kar1p is essential for microtubule function during karyogamy
The spindle pole body component Kar1p has a function in nuclear fusion during conjugation, a process known as karyogamy. The molecular role of Kar1p during this process is poorly understood. Here weExpand
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