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Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter
Transcriptional activation of a gene involves an orchestrated recruitment of components of the basal transcription machinery and intermediate factors, concomitant with an alteration in local… Expand
Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction…
- R. Métivier, G. Penot, G. Flouriot, F. Pakdel
- Medicine, Biology
- Molecular endocrinology
- 1 November 2001
The transcriptional activity of ERalpha (or NR3A1) after binding of ligand is mediated through synergistic action between activation functions (AFs) AF-1 and AF-2 and the transcriptional machinery.… Expand
A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains.
The functional interplay between different domains of estrogen receptor-alpha (ERalpha, NR3A1) is responsible for the overall properties of the full-length protein. We previously identified an… Expand
Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes.
Unliganded (apo-) estrogen receptor alpha (ERalpha, NR3A1) is classically considered as transcriptionally unproductive. Reassessing this paradigm demonstrated that apo-human ERalpha (ERalpha66) and… Expand
The human estrogen receptor-alpha isoform hERalpha46 antagonizes the proliferative influence of hERalpha66 in MCF7 breast cancer cells.
The expression of two human estrogen receptor-alpha (hERalpha) isoforms has been characterized within estrogen receptor-alpha-positive breast cancer cell lines such as MCF7: the full-length… Expand
Transcriptional complexes engaged by apo‐estrogen receptor‐α isoforms have divergent outcomes
Unliganded (apo‐) estrogen receptor α (ERα, NR3A1) is classically considered as transcriptionally unproductive. Reassessing this paradigm demonstrated that apo‐human ERα (ERα66) and its N‐terminally… Expand
The Relative Contribution Exerted by AF-1 and AF-2 Transactivation Functions in Estrogen Receptor α Transcriptional Activity Depends upon the Differentiation Stage of the Cell*
- Yohann Mérot, R. Métivier, +6 authors G. Flouriot
- Medicine, Biology
- Journal of Biological Chemistry
- 18 June 2004
The activity of the transactivation functions (activation function (AF)-1 and AF-2) of the estrogen receptor α (ERα) is cell-specific. This study aimed to decipher the yet unclear mechanisms involved… Expand
Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex
- Jean-Marc Blouin, G. Penot, +7 authors S. Bortoli
- Biology, Medicine
- International journal of cancer
- 1 June 2011
Butyrate, a short‐chain fatty acid produced by the colonic bacterial fermentation is able to induce cell growth inhibition and differentiation in colon cancer cells at least partially through its… Expand
The Human Estrogen Receptor-α Isoform hERα46 Antagonizes the Proliferative Influence of hERα66 in MCF7 Breast Cancer Cells
The expression of two human estrogen receptor-α (hERα) isoforms has been characterized within estrogen receptor-α-positive breast cancer cell lines such as MCF7: the full-length hERα66 and the N… Expand
Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats.
- Emilie Distel, Graziella Penot, Thomas Cadoudal, Irène Balguy, Sylvie Durant, Chantal Benelli
- Biology, Medicine
- 1 August 2012
The epicardial adipose tissue (EAT) is "hypertrophied" in the obese. Thiazolidinediones are anti-diabetic, hypolipidemic drugs and are selective agonists for the gamma isoform of peroxisome… Expand