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The Genome of the Diatom Thalassiosira Pseudonana: Ecology, Evolution, and Metabolism
Diatoms are unicellular algae with plastids acquired by secondary endosymbiosis. They are responsible for ∼20% of global carbon fixation. We report the 34 million–base pair draft nuclear genome ofExpand
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Proteomic analysis of a eukaryotic cilium
Cilia and flagella are widespread cell organelles that have been highly conserved throughout evolution and play important roles in motility, sensory perception, and the life cycles of eukaryotesExpand
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Chlamydomonas IFT88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg737, Are Required for Assembly of Cilia and Flagella
Intraflagellar transport (IFT) is a rapid movement of multi-subunit protein particles along flagellar microtubules and is required for assembly and maintenance of eukaryotic flagella. We cloned andExpand
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The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.
Eukaryotic cilia are assembled via intraflagellar transport (IFT) in which large protein particles are motored along ciliary microtubules. The IFT particles are composed of at least 17 polypeptidesExpand
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The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation
The smallest known eukaryotes, at ≈1-μm diameter, are Ostreococcus tauri and related species of marine phytoplankton. The genome of Ostreococcus lucimarinus has been completed and compared with thatExpand
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The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance
Approximately 10% of the photoreceptor outer segment (OS) is turned over each day, requiring large amounts of lipid and protein to be moved from the inner segment to the OS. Defects inExpand
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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
The Bardet-Biedl syndrome protein complex (BBSome) is a cargo adapter rather than an essential part of the intraflagellar transport (IFT) machinery.
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A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT)
Several enzymes, including cytoplasmic and flagellar outer arm dynein, share an M r 8,000 light chain termed LC8. The function of this chain is unknown, but it is highly conserved between a wideExpand
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A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney
Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by the formation of multiple kidney cysts that are thought to result from over-proliferation of epithelialExpand
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The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly
Dyneins are microtubule-based molecular motors involved in many different types of cell movement. Most dynein heavy chains (DHCs) clearly group into cytoplasmic or axonemal isoforms. However, DHC1bExpand
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