• Publications
  • Influence
  • 313
  • 27
Association of Genetic Mutations inPlasmodium vivax dhfr with Resistance to Sulfadoxine-Pyrimethamine: Geographical and Clinical Correlates
ABSTRACT Mutations in the Plasmodium falciparum gene (dhfr) encoding dihydrofolate reductase are associated with resistance to antifols. Plasmodium vivax, the more prevalent malaria parasite in AsiaExpand
  • 118
  • 17
Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.
There is no reliable means of detecting latent M. tuberculosis infection, and even in patients with active tuberculosis, infection is often unconfirmed. We hypothesized that M. tuberculosisExpand
  • 464
  • 16
  • PDF
Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1β on Tuberculosis
Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin (IL)-1β and itsExpand
  • 283
  • 15
  • PDF
Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis-Infected Individuals: Associations with Clinical Disease State and Effect of Treatment1
The wide spectrum of clinical outcomes following infection with Mycobacterium tuberculosis is largely determined by the host immune response; therefore, we studied several clinically defined groupsExpand
  • 372
  • 12
Severe anaemia in children living in a malaria endemic area of Kenya
Severe anaemia is an important cause of morbidity and mortality in African children, but the causes, particularly falciparum malaria, are difficult to determine. We assessed the contribution ofExpand
  • 190
  • 10
Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients
Dick Menzies and colleagues report findings from a collaborative, individual patient-level meta-analysis of treatment outcomes among patients with multidrug-resistant tuberculosis.
  • 445
  • 9
  • PDF
UK malaria treatment guidelines.
Malaria is the tropical disease most commonly imported into the UK, with 1500-2000 cases reported each year, and 10-20 deaths. Approximately three-quarters of reported malaria cases in the UK areExpand
  • 281
  • 9
  • PDF
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting withExpand
  • 204
  • 9
  • PDF
Improved Diagnostic Evaluation of Suspected Tuberculosis
Context Can new T-cellbased blood tests rule out active tuberculosis? Contribution In this study involving 389 adults with moderate to high suspicion of active tuberculosis, the sensitivity of a newExpand
  • 153
  • 9
  • PDF