G. Pasterkamp

Defining the role of common variation in the genomic and biological architecture of adult human height

Andrew R Wood, Tönu Esko, +441 authors Timothy M. Frayling
Nature Genetics
2014

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different… (More)

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.

Morteza Naghavi, P. Scott Libby, +55 authors James T. Willerson
Circulation
2003

Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major advances in treatment of coronary heart… (More)

Multiple complex coronary plaques in patients with acute myocardial infarction.

G. Pasterkamp, A Vink, Christoph Borst
The New England journal of medicine
2001

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

Ruenn Chai Lai, Fatih Arslan, +10 authors Sai Kiang Lim
Stem cell research
2010

Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100… (More)

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.

Morteza Naghavi, Peter Libby, +55 authors James T. Willerson
Circulation
2003

Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major advances in treatment of coronary heart… (More)

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial…

Fatih Arslan, Ruenn Chai Lai, +9 authors Dominique Paschalis Victor de Kleijn
Stem cell research
2013

We have previously identified exosomes as the paracrine factor secreted by mesenchymal stem cells. Recently, we found that the key features of reperfusion injury, namely loss of ATP/NADH, increased… (More)

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

Aysu Okbay, Bart M. L. Baselmans, +184 authors David Cesarini
Nature Genetics
2016

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is… (More)

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

Soraya Taleb, Melissa A Romain, +10 authors Ziad Mallat
The Journal of experimental medicine
2009

Atherosclerosis is an inflammatory vascular disease responsible for the first cause of mortality worldwide. Recent studies have clearly highlighted the critical role of the immunoinflammatory balance… (More)

Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury.

Leo Timmers, José P. S. Henriques, +9 authors Imo E. Hoefer
Journal of the American College of Cardiology
2009

OBJECTIVES This study sought to examine whether exenatide is capable of reducing myocardial infarct size. BACKGROUND Exenatide is a glucagon-like peptide (GLP)-1 analogue with insulinotropic and… (More)

Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study.

Willem E. Hellings, Wouter Dirix Peeters, +10 authors G. Pasterkamp
Circulation
2010

BACKGROUND Identification of patients at risk for primary and secondary manifestations of atherosclerotic disease progression is based mainly on established risk factors. The atherosclerotic plaque… (More)

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