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- Publications
- Influence
The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective.
- O. Semino, G. Passarino, +14 authors P. Underhill
- Medicine
- Nature Reviews Genetics
- 2000
A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied.… Expand
The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
- P. Underhill, G. Passarino, +5 authors L. Cavalli-Sforza
- Biology, Medicine
- Annals of human genetics
- 1 January 2001
Although molecular genetic evidence continues to accumulate that is consistent with a recent common African ancestry of modern humans, its ability to illuminate regional histories remains incomplete.… Expand
Y chromosome sequence variation and the history of human populations
- P. Underhill, P. Shen, +18 authors P. Oefner
- Biology, Medicine
- Nature Genetics
- 1 November 2000
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting… Expand
Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa
- L. Quintana-Murci, O. Semino, Hans-J. Bandelt, G. Passarino, K. McElreavey, A. Santachiara‐Benerecetti
- Biology, Medicine
- Nature Genetics
- 1 December 1999
The out-of-Africa scenario has hitherto provided little evidence for the precise route by which modern humans left Africa. Two major routes of dispersal have been hypothesized: one through North… Expand
The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective.
- O. Semino, G. Passarino, +14 authors P. Underhill
- Biology
- 10 November 2000
A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied.… Expand
The Role of Selection in the Evolution of Human Mitochondrial Genomes
- T. Kivisild, P. Shen, +14 authors P. Oefner
- Biology, Medicine
- Genetics
- 1 January 2006
High mutation rate in mammalian mitochondrial DNA generates a highly divergent pool of alleles even within species that have dispersed and expanded in size recently. Phylogenetic analysis of 277… Expand
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between… Expand
Origins and divergence of the Roma (gypsies).
- D. Gresham, B. Morar, +14 authors L. Kalaydjieva
- Biology, Medicine
- American journal of human genetics
- 1 December 2001
The identification of a growing number of novel Mendelian disorders and private mutations in the Roma (Gypsies) points to their unique genetic heritage. Linguistic evidence suggests that they are of… Expand
Y-chromosome and mtDNA polymorphisms in Iraq, a crossroad of the early human dispersal and of post-Neolithic migrations.
- N. Al-Zahery, O. Semino, +4 authors A. Santachiara‐Benerecetti
- Biology, Medicine
- Molecular phylogenetics and evolution
- 1 September 2003
Analyses of mtDNA and Y-chromosome variation were performed in a sample of Iraqis, a scarcely investigated population of the "Fertile Crescent." A total of 216 mtDNAs were screened for the diagnostic… Expand
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
- J. Deelen, M. Beekman, +84 authors P. Slagboom
- Biology, Medicine
- Human molecular genetics
- 31 March 2014
The genetic contribution to the variation in human lifespan is ∼25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We… Expand