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Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction*
The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1.
Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
It is found that diet‐induced insulin resistance promoted amyloidogenic β‐amyloid (Aβ) A β1–40 and Aβ1–42 peptide generation in the brain that corresponded with increased γ‐secretase activities and decreased insulin degrading enzyme (IDE) activities.
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia.
Therapeutic preservation of neuronal PGC-1alpha expression promotes the nonamyloidogenic processing of amyloid precursor protein precluding the generation of ameloidogenic Abeta peptides.
Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction
Identification of potential CSF biomarkers in ALS
Additional application of a “three-protein” biomarker model to current diagnostic criteria may provide an objective biomarker pattern to help identify patients with ALS.
Complement‐derived anaphylatoxin C5a protects against glutamate‐mediated neurotoxicity
The studies indicate that C5a may inhibit glutamate‐mediated neuronal death through partial inhibition of caspase‐3 activity, and suggest a novel noninflammatory role for C 5a in modulating neuronal responses to excitotoxins.
Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro.
Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease.
Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). We screened 55 clinically prescribed antihypertensive medications for…
Regional distribution of cyclooxygenase‐2 in the hippocampal formation in Alzheimer's disease
- L. Ho, Cristiana Pieroni, D. Winger, D. Purohit, P. Aisen, G. Pasinetti
- BiologyJournal of neuroscience research
- 1 August 1999
The results indicate elevated expression of neuronal COX‐2 in subregions of the hippocampal formation in AD and that such elevation may potentiate Aβ‐mediated oxidative stress.
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
This is the first study showing that diet, specifically a KD, alters the progression of the clinical and biological manifestations of the G93A SOD1 transgenic mouse model of ALS, and these effects may be due to the ability of ketone bodies to promote ATP synthesis and bypass inhibition of complex I in the mitochondrial respiratory chain.