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Mechanisms of prion protein assembly into amyloid
- J. Stöhr, N. Weinmann, +7 authors D. Riesner
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 19 February 2008
The conversion of the α-helical, cellular isoform of the prion protein (PrPC) to the insoluble, β-sheet-rich, infectious, disease-causing isoform (PrPSc) is the key event in prion diseases. In an… Expand
RNA expression Bcl-W, a new related protein Bcl-2 family, and caspase-3 in isolated Sertoli cells from pre-pubertal rat testes
- A. Giannattasio, G. Angeletti, +9 authors G. Lombardi
- Biology, Medicine
- Journal of endocrinological investigation
- 1 July 2002
Apoptosis has a major role in molding the embryo, in the maintenance of tissue homeostasis, and in the defense against pathogens, while its disgregulation is strongly implicated in cancer as well as… Expand
Spontaneous and BSE-prion-seeded amyloid formation of full length recombinant bovine prion protein.
- G. Panza, J. Stöhr, +5 authors E. Birkmann
- Biology, Medicine
- Biochemical and biophysical research…
- 5 September 2008
The conversion of the cellular isoform of the prion protein into the pathogenic isoform PrP(Sc) is the key event in prion diseases. The disease can occur spontaneously genetically or by infection. In… Expand
Amyloid formation: age-related mechanism in Creutzfeldt-Jakob disease?
Protein aggregation occurs in many age-related neurodegenerative diseases, where it can lead to deposits of naturally occurring proteins in the brain. In case of Creutzfeldt-Jakob disease (CJD),… Expand
Molecular Interactions between Prions as Seeds and Recombinant Prion Proteins as Substrates Resemble the Biological Interspecies Barrier In Vitro
Prion diseases like Creutzfeldt-Jakob disease in humans, Scrapie in sheep or bovine spongiform encephalopathy are fatal neurodegenerative diseases, which can be of sporadic, genetic, or infectious… Expand
Aggregation and amyloid fibril formation of the prion protein is accelerated in the presence of glycogen.
Prion diseases like Creutzfeldt-Jakob disease in humans or scrapie in sheep and goats are infectious neurodegenerative diseases. Their infectious agent, called prion, is composed mainly of aggregated… Expand
Influence of the maillard reaction to prion protein aggregation.
Prion diseases are fatal neurodegenerative diseases that occur either spontaneously or genetically or are caused by infection. Spontaneously occurring prion diseases are age related. The infectious… Expand