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Enzymatic stability, solution structure, and antiproliferative effect on prostate cancer cells of leuprolide and new gonadotropin-releasing hormone peptide analogs.
Analogs of GnRH, including [DLeu6, desGly1o]-GnRH-NHEt (leuprolide, commercial product), have been widely used in oncology to induce reversible chemical castration. Several studies have providedExpand
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Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies.
The significant antifungal activity of a series of sulfonamide-1,2,4-triazole and 1,3,4-thiazole derivatives against a series of micromycetes, compared to the commercial fungicide bifonazole has beenExpand
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Structural studies and cytotoxicity assays of “aggregation‐prone” IAPP8–16 and its non‐amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin
Amyloid deposits to the islets of Langerhans are responsible for the gradual loss of pancreatic β‐cells leading to type II diabetes mellitus. Human mature islet amyloid polypeptide (hIAPP), aExpand
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Further studies on the antineoplastic activity of homo-aza-steroidal esters.
The modified steroidal alkylating agents, 17 beta-hydroxy-3-aza-A-homo-4 alpha-androsten-4- one(p-[bis(2-chloroethyl)amino]phenyl)butyrate(1),3 alpha-hydroxy- 13,17-seco-5 alpha- butyrate(2),3Expand
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Synthesis of a new nor-aza-steroidal ester of p-N,N-bis-(2-chloroethyl)aminophenylbutyric acid and in vitro study of its mutagenicity and clastogenicity.
A new nor-aza-steroidal ester of chlorambucil has been synthesized. The study of the mitotic index in CHO and HeLa cells treated with this compound showed that it may be a cytostatic drug. It wasExpand
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On the formation of estrone lactam esters of N,N‐bis(2‐chloroethyl)aminocinnamic acid isomers, p‐N,N‐bis(2‐chloroethyl)aminophenylbutyric acid and their antitumor activity
New estrone-lactam esters, 17α-aza-D-homo-Δ1,3,5(10)-estratrien-3-ol-17-one-N,N-bis(2-chloroethyl)-aminocinnamic isomers and p-N,N-bis(2-chloroethyl)aminophenylbutyrate have been synthesized andExpand
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Synthesis of Heterocyclic Steroids
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