• Publications
  • Influence
Genetic and Hormonal Regulation of Tryptophan–Kynurenine Metabolism
  • G. Oxenkrug
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 December 2007
Impairment of cognition that is caused by (or associated with) vascular factors has been termed vascular cognitiveimpairment (VCI). The hallmark of VCI is an impairment of brain executive, orExpand
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Metabolic syndrome, age‐associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism
  • G. Oxenkrug
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 June 2010
The neuroendocrine theory of aging identified a cluster of conditions (hypertension, obesity, dyslipidemia, diabetes type 2, menopause, late onset depression, vascular cognitive impairment,Expand
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Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.
  • G. Oxenkrug
  • Medicine
  • The Israel journal of psychiatry and related…
  • 2010
The original 1969 Lancet paper proposed in depression the activity of liver tryptophan-pyrrolase is stimulated by raised blood corticosteroids levels, and metabolism of tryptophan is shunted awayExpand
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Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
Abstract: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and outer membrane. The pores regulate transport of ions and peptides inExpand
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Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.
Abstract Psychic depression may result from deficiency of brain serotonin. It is suggested that in depression the production of tryptophane pyrrolase by the liver is stimulated by raisedExpand
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Minocycline effect on life and health span of Drosophila melanogaster.
Up-regulation of kynurenine (KYN) pathway of tryptophan (TRP) was suggested as one of the mechanisms of aging and aging-associated disorders. Genetic and pharmacological impairment of TRP - KYNExpand
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Serotonin-kynurenine hypothesis of depression: historical overview and recent developments.
This mini-review focuses on the studies of late Prof. IP Lapin (1903 - 2012) and his research team on the role of methoxyindole and kynurenine (KYN) pathways of tryptophan (TRP) metabolism in theExpand
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Antidepressive and antihypertensive effects of MAO-A inhibition: role of N-acetylserotonin. A review.
Acute administration of irreversible and reversible selective MAO-A inhibitors and high doses (or chronic administration of low doses) of relatively selective MAO-B inhibitors (but not of highlyExpand
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Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of N‐Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin‐Primed Frogs
The ability of methylene blue (MB) to inhibit the nitric oxide–induced stimulation of N‐methyl‐d‐aspartate receptors has been suggested as a possible mechanism of MB's clinical antidepressant action.Expand
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Quinone reductase 2 and antidepressant effect of melatonin derivatives
Melatonin and its immediate precursor, N‐acetylserotonin (NAS), exert antidepressant effects in experimental models and clinical studies. We reported that melatonin and NAS decreased immobility timeExpand
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