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Angiotensin-converting enzyme 2 is an essential regulator of heart function
TLDR
These genetic data for ACE2 show that it is an essential regulator of heart function in vivo and targeted disruption of ACE2 in mice results in a severe cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart.
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
TLDR
An analysis of single-cell transcriptomics datasets from different tissues shows that ACE2 and TMPRSS2 are co-expressed in respiratory, corneal and intestinal epithelial cell populations, and that respiratory expression of ACE2 is associated with genes involved in innate immunity.
SARS‐coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS
TLDR
This study has shown that angiotensin converting enzyme 2 (ACE2) is a functional receptor for severe acute respiratory syndrome (SARS) coronavirus and is highly expressed in the lungs and heart and patients with SARS also suffered from cardiac disease.
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
TLDR
A review summarizes the progress over the past 20 years, highlighting the critical role of ACE2 as the novel SARS-CoV-2 receptor and as the negative regulator of the renin-angiotensin system, together with implications for the coronavirus disease 2019 pandemic and associated cardiovascular diseases.
Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.
TLDR
The transcriptional and post-transcriptional regulation of ACE2 and the role of the ACE2/Ang 1-7 axis in cardiac physiology and in the pathophysiology of HF are discussed and the pharmacological and therapeutic potential of enhancing ACE2 /Ang1-7 action as a novel therapy for HF is highlighted.
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
TLDR
The results indicate that cardiac LVDCCs are key transporters of iron into cardiomyocytes under iron-overloaded conditions, and potentially represent a new therapeutic target to reduce the cardiovascular burden from iron overload.
Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction
TLDR
Elevated Ang II induced hypertension, myocardial hypertrophy, fibrosis, and diastolic dysfunction were exacerbated by ACE2 deficiency, whereas rhACE2 attenuated Ang II– and pressure-overload–induced adverse myocardia remodeling, suggesting ACE2 is an important negative regulator of Ang II-induced heart disease and suppresses adverse myCardial remodeling.
Regulation of cardiac excitation–contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito)
TLDR
Evidence supporting a modulatory role of Ito in ECC through its influence onICa,L, and possibly ICa,NCX is reviewed and differential effects of Iti between different species, between different regions of the heart, and in heart disease are discussed.
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